Table 3

Manganese superoxide dismutase -102 genotype: overall and recurrence-free survivals with radiation therapy

Genotype
Cases
Deaths
Hazard ratio minimally adjusteda (95% confidence interval)
Hazard ratio fully adjustedb (95% confidence interval)

Overall survival
150
33
P for trend = 0.67
P for trend = 0.91
     CC
93
20
1 (reference)
1 (reference)
     CT
51
11
0.97 (0.46–2.04)
0.74 (0.35–1.58)
     TT
6
2
1.95 (0.45–8.49)
2.23 (0.46–10.79)





     CC
93
20
1 (reference)
1 (reference)
     CT + TT
57
13
1.05 (0.52–2.12)
0.82 (0.40–1.70)
Recurrence-free survival
145
40
P for trend = 0.14
P for trend = 0.03
     CC
90
29
1 (reference)
1 (reference)
     CT
50
10
0.57 (0.28–1.18)
0.40 (0.18–0.86)
     TT
5
1
0.60 (0.08–4.47)
0.69 (0.09–5.46)





     CC
90
29
1 (reference)
1 (reference)
     CT + TT
55
11
0.57 (0.28–1.16)
0.42 (0.20–0.87)

CC, homozygous for the wild-type manganese superoxide dismutase gene; CT, heterozygous for the variant genotype; TT, homozygous for the variant genotype. aMinimally adjusted model: age. bFully adjusted model: age, stage with node status at diagnosis, race, estrogen receptor status, and progesterone receptor status.

Martin et al. Breast Cancer Research 2006 8:R45   doi:10.1186/bcr1532