Table 4

Manganese superoxide dismutase -102 genotype: overall and recurrence-free survivals with adjuvant chemotherapy

Genotype
Cases
Deaths
Hazard ratio minimally adjusteda (95% confidence interval)
Hazard ratio fully adjustedb (95% confidence interval)

Overall survival
230
75
P for trend = 0.46
P for trend = 0.42
     CC
140
49
1 (reference)
1 (reference)
     CT
73
21
0.83 (0.49–1.38)
0.67 (0.38–1.17)
     TT
17
5
0.81 (0.32–2.04)
1.07 (0.42–2.74)





     CC
140
49
1 (reference)
1 (reference)
     CT + TT
90
26
0.82 (0.51–1.33)
0.73 (0.44–1.22)
Recurrence-free survival
220
85
P for trend = 0.16
P for trend = 0.12
     CC
136
57
1 (reference)
1 (reference)
     CT
68
24
0.79 (0.49–1.28)
0.64 (0.38–1.07)
     TT
16
4
0.55 (0.20–1.52)
0.73 (0.26–2.049)





     CC
136
57
1 (reference)
1 (reference)
     CT + TT
84
28
0.75 (0.47–1.18)
0.65 (0.40–1.05)

CC, homozygous for the wild-type manganese superoxide dismutase gene; CT, heterozygous for the variant genotype; TT, homozygous for the variant genotype. aMinimally adjusted model: age. bFully adjusted model: age, stage with node status at diagnosis, race, estrogen receptor status, and progesterone receptor status.

Martin et al. Breast Cancer Research 2006 8:R45   doi:10.1186/bcr1532