Table 1 |
||||||||||
|
Clinicopathological characteristics and gene expression variation of each patient |
||||||||||
|
Difference in gene expression between CB and ST (ΔCt [GeneST] – ΔCt [GeneCB]) |
||||||||||
|
|
||||||||||
|
Patient number |
Age |
Time between CB and ST (days) |
Histology |
Tumor diameter (cm) |
Grade |
Lymph node involvement |
Correlation (rs) between paired CB and ST |
PAI-1 |
COX-2 |
ERBB2 |
|
|
||||||||||
|
1 |
68 |
7 |
Ductal |
3.3 |
3 |
Negative |
0.97 |
-0.39 |
-0.15 |
-0.08 |
|
2 |
59 |
8 |
Ductal |
1.8 |
3 |
Negative |
0.98 |
-1.68 |
-0.20 |
0.52 |
|
3 |
49 |
21 |
Ductal |
3.3 |
2 |
Positive |
0.98 |
-1.19 |
-1.03 |
0.62 |
|
4 |
57 |
13 |
Ductal |
1.1 |
1 |
Positive |
0.89 |
-0.63 |
0.61 |
-0.02 |
|
5 |
63 |
14 |
Ductal |
9.0 |
2 |
Negative |
0.97 |
-1.41 |
-1.80 |
1.40 |
|
6 |
60 |
21 |
Ductulo-lobular |
2.7 |
1 |
Positive |
0.98 |
-1.38 |
-2.41 |
0.23 |
|
7 |
80 |
12 |
Ductal |
3.1 |
1 |
Positive |
0.95 |
-2.62 |
-1.39 |
0.44 |
|
8 |
81 |
14 |
Lobular |
2.8 |
2 |
Positive |
0.94 |
-3.78 |
-3.73 |
0.29 |
|
9 |
34 |
14 |
Ductal |
1.8 |
2 |
Negative |
0.95 |
-3.16 |
-1.37 |
0.12 |
|
10 |
68 |
10 |
Ductal |
0.9 |
2 |
Micrometastasis |
0.87 |
-3.57 |
-7.27 |
1.01 |
|
11 |
65 |
16 |
Lobular |
1.9 |
1 |
Negative |
0.89 |
-5.16 |
-0.80 |
-0.02 |
|
12 |
80 |
13 |
Ductal |
6.0 |
3 |
Positive |
0.86 |
-2.16 |
-0.20 |
0.63 |
|
13 |
59 |
2 |
Apocrine |
2.7 |
3 |
Negative |
0.98 |
-1.18 |
-4.64 |
-0.27 |
|
14 |
73 |
12 |
Lobular |
1.9 |
2 |
Positive |
0.95 |
-4.60 |
-3.97 |
-1.85 |
|
15 |
61 |
1 |
Lobular |
2.3 |
2 |
Positive |
0.89 |
-1.88 |
-1.61 |
-0.94 |
|
16 |
73 |
22 |
Ductal |
1.9 |
2 |
Negative |
0.98 |
-1.28 |
-0.34 |
0.26 |
|
17 |
58 |
3 |
Ductal |
9.0 |
2 |
Positive |
0.96 |
-0.48 |
0.26 |
-0.42 |
|
19 |
68 |
13 |
Ductal |
1.2 |
1 |
Negative |
0.97 |
-2.18 |
-2.62 |
0.31 |
|
18a |
67 |
11 |
Ductal |
1.5 |
2 |
Micrometastasis |
NA |
NA |
NA |
NA |
|
20 |
44 |
13 |
Ductulo-lobular |
3.2 |
3 |
Positive |
0.98 |
-0.12 |
0.01 |
0.19 |
|
21 |
71 |
20 |
Ductulo-lobular |
1.7 |
3 |
Negative |
0.95 |
-3.15 |
-1.69 |
0.26 |
|
22 |
53 |
5 |
Ductal |
1.3 |
2 |
Negative |
0.92 |
-2.81 |
-5.48 |
-0.08 |
|
|
||||||||||
|
aRNA in the core biopsy (CB) of this patient was degraded and, therefore, omitted from the study. COX, cyclooxygenase; NA, not available; PAI-1, Plasminogen Activator Inhibitor-1; ST, surgical tumor tissue specimen. |
||||||||||
|
Zanetti-Dällenbach et al. Breast Cancer Research 2006 8:R51 doi:10.1186/bcr1542 |
||||||||||
