Table 4

AR exon 1 CAG Repeat length and family history in the NHS and the WHS

Family history

Genotype^a [CAG]_n

1990–1996 OR (95% CI)^b

1998–2000 OR (95% CI)^b

WHS OR (95% CI)^b

NHS and WHS Combined OR (95% CI)^b

no

<22

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

no

≥22

0.9 (0.8 to 1.2)

1.0 (0.7 to 1.4)

0.7 (0.5 to 1.0)

1.0 (0.9 to 1.2)

yes

<22

1.0 (0.6 to 1.7)

2.0 (0.9 to 4.2)

1.6 (0.8 to 3.0)

1.1 (0.9 to 1.5)

yes

≥22

1.7 (1.2 to 2.4)

1.6 (0.9 to 2.6)

1.1 (0.7 to 1.8)

1.3 (1.1 to 1.6)

no

<22

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

no

≥23

0.9 (0.7 to1.2)

0.9 (0.7 to 1.3)

0.7 (0.5 to 1.0)

1.0 (0.9 to 1.2)

yes

<22

1.0 (0.8 to 1.4)

1.9 (0.9 to 4.1)

1.6 (0.8 to 3.0)

1.1 (0.9 to 1.5)

yes

≥23

1.8 (1.2 to 2.5)

1.5 (0.9 to 2.6)

1.0 (0.6 to 1.5)

1.4 (1.1 to 1.8)

no

<22

1.00 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

no

≥25

1.0 (0.8 to 1.4)

0.9 (0.6 to 1.3)

0.7 (0.5 to 1.1)

1.0 (0.9 to 1.2)

yes

<22

1.1 (0.6 to 1.8)

1.8 (0.9 to 4.0)

1.6 (0.8 to 3.0)

1.1 (0.9 to 1.5)

yes

≥25

2.0 (1.3 to 3.1)

1.5 (0.7 to 3.0)

0.7 (0.4 to 1.3)

1.5 (1.1 to 2.0)

no

<22

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

1.0 (Ref.)

no

≥27

1.1 (0.7 to 1.7)

1.4 (0.8 to 2.5)

0.8 (0.5 to 1.3)

1.1 (0.9 to 1.4)

yes

<22

1.1 (0.6 to 1.9)

2.0 (0.9 to 4.6)

1.6 (0.8 to 3.0)

1.1 (0.9 to 1.6)

yes

≥27

1.6 (0.8 to 3.1)

2.1 (0.7 to 6.5)

0.7 (0.3 to 1.8)

1.4 (0.9 to 2.1)

^aAR genotype defined as having one or more long alleles ≥22, 23, 25, or 27 versus both alleles <22; ^bunconditional, unadjusted logistic regression. AR, androgen receptor; CI, confidence interval; NHS, Nurses' Health Study; OR, odds ratio; Ref., Reference category; WHS, Women's Health Study.

Cox et al. Breast Cancer Research 2006 8:R54   doi:10.1186/bcr1602