Table 4 |
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|
Adjusted means of absolute mammographic densitya (95% confidence interval) in quartiles of plasma leptin concentration, stratified by tertiles of nondense mammographic area (n = 967) |
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|
Nondense mammographic area |
Quartile of plasma leptin concentration |
Ptrend |
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|
|
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|
<9.1 ng/ml |
9.1–14.5 ng/ml |
14.6–24.0 ng/ml |
>24.0 ng/ml |
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|
|
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|
First tertile (n) |
140 |
90 |
55 |
40 |
|
|
Mammographic density, adjustedb |
19.1(16.2–22.6) |
17.8 (14.7–21.5) |
16.8 (13.5–20.9) |
19.4 (15.0–25.2) |
0.7 |
|
Mammographic density, adjustedb, additionally adjusted for BMIc |
22.1 (18.2–26.8) |
19.0 (15.6–23.1) |
17.5 (14.0–21.9) |
18.7 (14.4–24.3) |
0.12 |
|
Second tertile (n) |
68 |
82 |
94 |
75 |
|
|
Mammographic density, adjustedb |
10.6 (7.8–14.5) |
14.1(10.4–19.1) |
13.2 (10.1–17.4) |
17.3 (13.1–22.8) |
0.02 |
|
Mammographic density, adjustedb, additionally adjusted for BMIc |
9.9 (7.2–13.6) |
14.0 (10.3–19.0) |
13.7 (10.3–18.2) |
19.6 (14.6–26.3) |
0.003 |
|
Third tertile (n) |
43 |
62 |
94 |
124 |
|
|
Mammographic density, adjustedb |
7.5 (4.9–11.6) |
10.4 (7.2–15.0) |
6.2 (4.5–8.5) |
7.0 (5.2–9.4) |
0.22 |
|
Mammographic density, adjustedb, additionally adjusted for BMIc |
8.2 (5.1–13.1) |
11.3 (7.7–16.7) |
7.5 (5.1–10.9) |
8.6 (5.9–12.5) |
0.63 |
|
|
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aMultiple linear regression. Absolute mammographic density was log-transformed, reported means are back-transformed. bAdjusted for age (tertiles), full-term pregnancies (none, 1–2, 3, >3), age at first birth (<20 years, 20–24 years, >24 years) and postmenopausal hormone therapy (current use/noncurrent use). cBody mass index (BMI), <23, 23–24, 25–26, 27–28, >28. |
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|
Stuedal et al. Breast Cancer Research 2006 8:R55 doi:10.1186/bcr1603 |
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