Table 5 |
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|
List of 78 genes able to discriminate between well/well-intermediately and intermediately-poorly/poorly differentiated DCIS |
||||
| Rank |
NKI ID |
Symbol |
Annotation |
Accession no. |
|
|
||||
| 1 |
111275 |
EST |
H20757 |
|
| 2 |
109268 |
ALDH3A2 |
Aldehyde dehydrogenase 3 family, member A2 |
AA633569 |
| 3 |
109236 |
BTD |
Biotinidase |
R17765 |
| 4 |
110384 |
KPNA2 |
Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
AA676460 |
| 5 |
131448 |
PLEKHG1 |
KIAA1209 protein |
AI301815 |
| 6 |
108691 |
ACK1 |
Activated p21cdc42Hs kinase |
AA427891 |
| 7 |
107840 |
EPC1 |
ESTs |
AA120875 |
| 8 |
126868 |
TMC4 |
DKFZP586J0619 protein |
AA991211 |
| 9 |
106257 |
FLJ32499 |
H. sapiens cDNA FLJ12749 fis, clone NT2RP2001149 |
W56590 |
| 10 |
128493 |
GMFG |
Glia maturation factor, gamma |
AI311932 |
| 11 |
128702 |
AI313031 |
||
| 12 |
129547 |
METAP2 |
Methionine aminopeptidase; eIF-2-associated p67 |
AA283030 |
| 13 |
111787 |
ZNF451 |
H. sapiens cDNA FLJ13010 fis, clone NT2RP3000542 |
AA486412 |
| 14 |
103209 |
RBMS1 |
H. sapiens mRNA; cDNA DKFZp564H0764 (from clone DKFZp564H0764) |
R62566 |
| 15 |
108595 |
CCL19 |
Small inducible cytokine subfamily A (Cys-Cys), member 19 |
AA680186 |
| 16 |
129267 |
AA609203 |
||
| 17 |
109127 |
ESR1 |
Oestrogen receptor 1 |
AA291749 |
| 18 |
100263 |
MYB |
V-myb avian myeloblastosis viral oncogene homolog |
N49284 |
| 19 |
100524 |
CELSR2 |
Cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog |
H39187 |
| 20 |
100260 |
MAL |
Mal, T-cell differentiation protein |
AA227885 |
| 21 |
102995 |
PIGT |
CGI-06 protein |
H82992 |
| 22 |
108649 |
Human clone 23948 mRNA sequence |
H15114 |
|
| 23 |
109246 |
BCL2 |
B-cell CLL/lymphoma 2 |
W63749 |
| 24 |
100203 |
TNFAIP3 |
Tumour necrosis factor, alpha-induced protein 3 |
AA476272 |
| 25 |
107809 |
XBP1 |
X-box binding protein 1 |
W90128 |
| 26 |
102921 |
H. sapiens mRNA; cDNA DKFZp434D0818 (from clone DKFZp434D0818) |
N95578 |
|
| 27 |
108671 |
BCAT2 |
Branched chain aminotransferase 2, mitochondrial |
AA436410 |
| 28 |
101925 |
EZH2 |
AA430744 |
|
| 29 |
123382 |
HIG1 |
Likely ortholog of mouse hypoxia induced gene 1 |
T74105 |
| 30 |
131187 |
KPNA2 |
Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
AA489087 |
| 31 |
111288 |
H. sapiens mRNA; cDNA DKFZp564C2063 (from clone DKFZp564C2063) |
AA416628 |
|
| 32 |
109170 |
C4A |
Complement component 4A |
AA664406 |
| 33 |
108203 |
TEGT |
Testis enhanced gene transcript (BAX inhibitor 1) |
AA629591 |
| 34 |
102639 |
EML2 |
Microtubule-associated protein like echinoderm EMAP |
R27580 |
| 35 |
131258 |
PSMA7 |
Proteasome (prosome, macropain) subunit, alpha type, 7 |
AI318565 |
| 36 |
123478 |
FLJ14712 |
Hypothetical protein FLJ14712 |
N79050 |
| 37 |
109415 |
FCGBP |
Fc fragment of IgG binding protein |
R52030 |
| 38 |
127815 |
PLAT |
Plasminogen activator, tissue |
R38933 |
| 39 |
115769 |
ESTs |
AA406313 |
|
| 40 |
106220 |
GIMAP5 |
Hypothetical protein FLJ11296 |
AA150443 |
| 41 |
128641 |
PTTG1 |
Pituitary tumour-transforming 1 |
AI362866 |
| 42 |
105439 |
TGOLN2 |
Trans-Golgi network protein (46-, 48-, 51-kD isoforms) |
T81338 |
| 43 |
101362 |
ERBB2 |
V-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 2 (neuro/glioblastoma
derived oncogene homolog) |
AA446928 |
| 44 |
108387 |
IDH2 |
Isocitrate dehydrogenase 2 (NADP+), mitochondrial |
AA679907 |
| 45 |
100352 |
TGOLN2 |
Trans-Golgi network protein (46-, 48-, 51-kD isoforms) |
H82891 |
| 46 |
107941 |
PLAC8 |
Hypothetical protein |
AA150263 |
| 47 |
100104 |
SELL |
Selectin L (lymphocyte adhesion molecule 1) |
H00662 |
| 48 |
110983 |
DLEU1 |
Deleted in lymphocytic leukaemia, 1 |
AA425755 |
| 49 |
108438 |
GRB7 |
Growth factor receptor-bound protein 7 |
H53703 |
| 50 |
107752 |
PAG |
Phosphoprotein associated with GEMs |
N50114 |
| 51 |
128532 |
LTB |
Lymphotoxin beta (TNF superfamily, member 3) |
AI351740 |
| 52 |
124620 |
ASTN2 |
KIAA0634 protein |
AA404602 |
| 53 |
102357 |
CHN1 |
Chimerin (chimaerin) 1 |
AA598668 |
| 54 |
109454 |
AKR7A2 |
Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) |
T62865 |
| 55 |
108678 |
CASP10 |
Caspase 10, apoptosis-related cysteine protease |
H80712 |
| 56 |
131111 |
CUGBP2 |
CUG triplet repeat, RNA-binding protein 2 |
AA047257 |
| 57 |
123475 |
C9orf87 |
Hypothetical protein FLJ10493 |
N53432 |
| 58 |
105013 |
EST |
H61003 |
|
| 59 |
100791 |
TDG |
Thymine-DNA glycosylase |
AA496947 |
| 60 |
100528 |
BCL2L2 |
BCL2-like 2 |
AA454588 |
| 61 |
116312 |
FLJ14299 |
Hypothetical protein FLJ14299 |
AA453170 |
| 62 |
100700 |
TRIB2 |
GS3955 protein |
AA458653 |
| 63 |
102004 |
PIK3R1 |
Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) |
R54050 |
| 64 |
104569 |
MYO1B |
H. sapiens cDNA FLJ20153 fis, clone COL08656, highly similar to AJ001381 H. sapiens incomplete cDNA for a mutated allele |
N95358 |
| 65 |
113907 |
SNRPB2 |
Small nuclear ribonucleoprotein polypeptide B" |
H00286 |
| 66 |
128683 |
WASL |
Wiskott-Aldrich syndrome-like |
AI261600 |
| 67 |
123768 |
DUSP22 |
Mitogen-activated protein kinase phosphatase x |
H42417 |
| 68 |
105099 |
RET |
Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid
carcinoma 1, Hirschsprung disease) |
H24956 |
| 69 |
116859 |
STMN1 |
Leukaemia-associated phosphoprotein p18 (stathmin) |
AA873060 |
| 70 |
111660 |
FLJ13710 |
ESTs |
AA120866 |
| 71 |
100112 |
SAA1 |
Serum amyloid A1 |
H25546 |
| 72 |
100840 |
THOC1 |
Nuclear matrix protein p84 |
AA129297 |
| 73 |
129239 |
EST, Moderately similar to AF119917 63 PRO2831 [H. sapiens] |
W95750 |
|
| 74 |
115662 |
GIMAP4 |
Hypothetical protein FLJ11110 |
AA406363 |
| 75 |
109607 |
HTPAP |
ESTs |
T48412 |
| 76 |
108692 |
EMP2 |
Epithelial membrane protein 2 |
T88721 |
| 77 |
105133 |
JUNB |
Jun B proto-oncogene |
N94468 |
| 78 |
129959 |
LOC283352 |
EST |
AI023540 |
|
|
||||
|
DCIS, ductal carcinoma in situ; EST, expressed sequence tag; NKI ID, Netherlands Cancer Institute (Amsterdam, The Netherlands) identification number. |
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|
Hannemann et al. Breast Cancer Research 2006 8:R61 doi:10.1186/bcr1613 |
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