Table 3

VDR genotype and postmenopausal breast cancer risk stratified by total calcium and vitamin D intakes^a

Total calcium (mg/day)

Total vitamin D (IU/day)

<902

902+

<222

222+

SNP

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

Fok 1

FF

1.00

-

0.91

(0.56–1.47)

1.00

-

0.89

(0.55–1.45)

Ff

0.79

(0.50–1.25)

0.80

(0.50–1.26)

0.72

(0.45–1.14)

0.88

(0.56–1.39)

ff

1.08

(0.56–2.09)

0.63

(0.32–1.24)

1.03

(0.53–1.99)

0.68

(0.36–1.29)

p_interaction = 0.34^b

p_interaction = 0.18

Taq1

tt or Tt

1.00

-

1.16

(0.81–1.65)

1.00

-

1.02

(0.70–1.49)

TT

1.24

(0.79–1.94)

0.64

(0.41–0.99)

0.88

(0.56–1.38)

0.77

(0.50–1.21)

p_interaction = 0.01

p_interaction = 0.36

Apa1

AA

1.00

-

0.86

(0.49–1.50)

1.00

-

0.86

(0.48–1.53)

Aa or aa

0.86

(0.53–1.38)

0.74

(0.47–1.17)

0.77

(0.49–1.20)

0.82

(0.52–1.31)

p_interaction = 0.77

p_interaction = 0.47

Bsm1

BB or Bb

1.00

-

1.05

(0.71–1.55)

1.00

-

0.90

(0.60–1.35)

bb

1.20

(0.73–1.95)

0.61

(0.38–0.96)

0.72

(0.44–1.18)

0.78

(0.49–1.26)

p_interaction = 0.01

p_interaction = 0.90

Poly(A) tail

SS or SL

1.00

-

1.16

(0.81–1.67)

1.00

-

0.96

(0.66–1.41)

LL

1.18

(0.74–1.87)

0.66

(0.42–1.04)

0.79

(0.50–1.26)

0.77

(0.49–1.21)

p_interaction = 0.02

p_interaction = 0.72

^aMultivariate adjusted models contain the SNP, dietary exposure, and interaction term and adjust for body mass index, history of breast cyst, hormone replacement therapy use, family history of breast cancer, education, parity and age at first birth combined, age at menarche, age at menopause, and total energy intake. ^bInteraction terms were created using continuous form of dietary variables. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; VDR, vitamin D receptor.

McCullough et al. Breast Cancer Research 2007 9:R9   doi:10.1186/bcr1642