Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer

Chin-Yo Lin1,2, Anders Ström3, Say Li Kong1, Silke Kietz3, Jane S Thomsen1, Jason BS Tee1, Vinsensius B Vega1, Lance D Miller1, Johanna Smeds4, Jonas Bergh4, Jan-Åke Gustafsson3,5 and Edison T Liu1*

Author Affiliations

1 Genome Institute of Singapore, 60 Biopolis Street, #02-01, Singapore 138672, Republic of Singapore

2 Department of Microbiology and Molecular Biology, Brigham Young University, 753 WIDB, Provo, UT 84602, USA

3 Center for Biotechnology, Karolinska Institute, Hälsovägen 7-9, 141 57 Huddinge, Novum, Sweden

4 Radiumhemmet, Karolinska Institute and University Hospital, S-171 76 Stockholm, Sweden

5 Department of Biosciences and Nutrition, Karolinska Institute, Hälsovägen 7-9, 141 57 Huddinge, Novum, Sweden

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Breast Cancer Research 2007, 9:R25 doi:10.1186/bcr1667

Published: 10 April 2007

Additional files

Additional file 1:

Cell line estrogen receptor beta overexpression and E2 treatment microarray data with log2-transformed fold-change data as compared to the untreated uninduced control at each time point.

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Additional file 2:

Uppsala patient information, including estrogen receptor (ER) beta transcript levels and ER alpha protein levels.

Format: XLS Size: 20KB Download file

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Additional file 3:

Gene ontology annotations (2002 version) made by Compugen USA, Inc. (Jamesburg, NJ, USA) for probes represented on the microarrays used for the cell line study.

Format: XLS Size: 2MB Download file

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