|
Tumour and patient characteristics, by DDRP mutation carrier status and previous RT exposure |
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| Characteristic |
Mutation positive (n = 51) |
Mutation negative (n = 196) |
||
| Previous RT |
No previous RT |
Previous RT |
No previous RT |
|
|
|
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| Age at first BC, years |
40.3 |
42.4 |
41.4 |
42.3 |
| Age at second BC, years |
48.1 |
51.8 |
51.1 |
54.2 |
| Chemotherapy, n (percentage) |
11 (27) |
1 (10) |
28 (22) |
5 (7) |
| Tumour size, cm |
1.8 |
2.9 |
2.2 |
2.3 |
| Lymph node positive, n (percentage) |
12 (29) |
1 (10) |
41 (32) |
4 (6) |
| RT dosea, Gy |
||||
| Mean (range) |
1.49 (0.27–3.73) |
1.55 (0.24–5.61) |
||
| Median |
1.32 |
1.40 |
||
| Third quartile |
1.79 |
1.89 |
||
|
DDRP, DNA-damage repair pathway; BC, breast cancer; RT, radiation treatment. aRadiation dose to the site of the breast where the tumour had developed. | ||||
Broeks et al. Breast Cancer Research 2007 9:R26 doi:10.1186/bcr1668 |
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