|
Frequencies of CBC patients carrying apathogenic DNA-damage repair pathway mutation |
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| Age (years) |
All CBC patients |
Previous RT |
No RT |
Carriers versus non-carriers |
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| n |
Percentage |
n |
Percentage |
n |
Percentage |
OR for CBC after RT |
95% CI |
|
|
|
||||||||
| <40 (n = 91) |
22/91 |
24 |
19/67 |
28 |
3/24 |
12 |
2.77 |
0.74–10.39 |
| 40–50 (n = 156) |
29/156 |
18.6 |
22/102 |
21.6 |
7/54 |
12.9 |
1.85 |
0.73–4.65 |
|
Results for all contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure, are presented, according to age at diagnosis of first primary breast cancer (before the age of 40 years or between 40 and 50 years of age). Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. RT, radiation treatment. | ||||||||
Broeks et al. Breast Cancer Research 2007 9:R26 doi:10.1186/bcr1668 |
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