Table 1 |
||||
|
Clinical and histopathological characteristics of cases included in the study |
||||
| All cases (n = 212) |
Microarray (n = 80) |
|||
|
|
|
|||
| Characteristics |
Number |
Percent |
Number |
Percent |
|
|
||||
| Age (year) |
||||
| <45 |
24 |
11.3 |
6 |
7.5 |
| 45–55 |
37 |
17.5 |
12 |
15.0 |
| 55–65 |
38 |
17.9 |
20 |
25.0 |
| 65–75 |
50 |
23.6 |
21 |
26.3 |
| ≥75 |
63 |
29.7 |
21 |
26.3 |
| Gender |
||||
| Female |
211 |
99.5 |
79 |
98.8 |
| Male |
1 |
0.5 |
1 |
1.2 |
| Type |
||||
| Ductal |
132 |
64.4 |
51 |
63.8 |
| Lobular |
53 |
25.8 |
22 |
27.5 |
| Mucinous |
8 |
3.9 |
3 |
3.8 |
| Medullary |
4 |
2.0 |
0 |
0 |
| DCIS with microinvasion |
1 |
0.5 |
1 |
1.3 |
| Tubulolobular |
2 |
1.0 |
2 |
2.5 |
| Other |
5 |
2.4 |
1a |
1.3 |
| Unknown |
7 |
0 |
||
| Tumor size |
||||
| pT1 (≤2 cm) |
71 |
34.6 |
20 |
26.0 |
| pT2 (>2 ≤5 cm) |
112 |
54.6 |
44 |
57.1 |
| pT3 (>5 cm) |
15 |
7.3 |
8 |
10.4 |
| pT4 (infiltrating growth) |
7 |
3.4 |
5 |
6.5 |
| Unknown |
7 |
3 |
||
| Node status |
||||
| pN0 (negative) |
95 |
44.8 |
33 |
41.3 |
| pN1 (1–3 positive) |
48 |
22.6 |
23 |
28.8 |
| pN2–N3 (≥4 positive) |
33 |
15.6 |
12 |
15.0 |
| pNX (Nodes not removed) |
36 |
17.0 |
12 |
15.0 |
| Grade |
||||
| 1 |
19 |
9.0 |
6 |
7.5 |
| 2 |
141 |
66.5 |
53 |
66.3 |
| 3 |
48 |
22.6 |
21 |
26.3 |
| Unknown |
4 |
0 |
||
| Estrogen receptor |
||||
| Positive |
109 |
57.7 |
45 |
62.5 |
| Negative |
80 |
42.3 |
27 |
37.5 |
| Unknown |
23 |
8 |
||
| Progesteron receptor |
||||
| Positive |
130 |
62.8 |
51 |
67.1 |
| Negative |
77 |
37.2 |
25 |
32.9 |
| Unknown |
5 |
4 |
||
| TP53 mutation |
||||
| Mutation |
48 |
23.6 |
20 |
25.0 |
| Wild type |
155 |
76.4 |
60 |
75.0 |
| Unknown |
9 |
0 |
||
| Gene expression group |
||||
| Luminal A |
23 |
28.8 |
||
| Highly proliferating luminal |
15 |
18.8 |
||
| Normal-like |
20 |
25.0 |
||
| Basal-like |
12 |
15.0 |
||
| ERBB2+ |
10 |
12.5 |
||
| Adjuvant therapy |
||||
| Radiation therapy |
||||
| Yes |
60 |
31.1 |
25 |
32.9 |
| No |
133 |
68.9 |
51 |
67.1 |
| Unknown |
19 |
4 |
||
| Chemotherapyb |
||||
| Yes |
27 |
12.9 |
11 |
14.1 |
| No |
182 |
87.1 |
67 |
85.9 |
| Unknown |
3 |
2 |
||
| Hormonal treatmentc |
||||
| Yes |
53 |
25.1 |
25 |
31.6 |
| No |
158 |
74.9 |
54 |
68.4 |
| Unknown |
1 |
|||
| Recurrence (distant metastisis) |
||||
| Positive |
72 |
34.1 |
34 |
42.5 |
| Negative |
139 |
65.9 |
46 |
57.5 |
| Unknown |
1 |
0 |
||
| Status |
||||
| Alive |
75 |
37.5 |
25 |
32.5 |
| Dead of disease |
63 |
31.5 |
30 |
39.0 |
| Dead of other cause |
60 |
30.0 |
20 |
26.0 |
| Emmigrated |
2 |
1.0 |
2 |
2.6 |
| Unknown |
12 |
3 |
||
|
|
||||
|
aRare type with a metaplastic core and spindle cell component. bCMF × 9 (cyclophosphamide, methotrexate, 5-fluorouracil). cTamoxifen; 2 years. DCIS, ductal carcinoma in situ. |
||||
|
Langerød et al. Breast Cancer Research 2007 9:R30 doi:10.1186/bcr1675 |
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