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Genes downregulated by AI treatment |
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| ID |
Symbol |
Description |
Unigene |
Fold |
LFDR |
|
|
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| HSI182A05 |
TFF1 |
Trefoil factor 1 (breast cancer, estrogen-inducible) |
Hs.162807 |
0.26 |
0.09 |
| HSI054D07 |
HBB |
Haemoglobin, beta |
Hs.523443 |
0.31 |
0.00 |
| HSI047B01 |
PDZK1 |
PDZ domain containing 1 |
Hs.444751 |
0.35 |
0.00 |
| HSI035H02 |
CYP2B6 |
Cytochrome P450, family 2B6 |
Hs.1360 |
0.41 |
0.04 |
| HSI075H09 |
AGR2 |
Anterior gradient 2 homolog (Xenopus laevis) |
Hs.530009 |
0.41 |
0.08 |
| HSI031E07 |
STARD10 |
START domain containing 10 |
Hs.188606 |
0.42 |
0.00 |
| HSI183G10 |
TFF3 |
Trefoil factor 3 (intestinal) |
Hs.82961 |
0.43 |
0.00 |
| HSI147F09 |
ZBTB20 |
Zinc finger and BTB domain containing 20 |
Hs.570657 |
0.45 |
0.00 |
| HSI182A08 |
STC2 |
Stanniocalcin 2 |
Hs.233160 |
0.47 |
0.00 |
| HSI147F08 |
KTN1 |
Kinectin 1 (kinesin receptor) |
Hs.509414 |
0.47 |
0.00 |
| HSI059H10 |
LOC143381 |
Hypothetical protein LOC143381 |
Hs.388347 |
0.47 |
0.00 |
| HSI147F10 |
MSI2 |
Musashi homolog 2 (Drosophila) |
Hs.134470 |
0.49 |
0.00 |
| HSI177G07 |
EST |
Transcribed locus |
Hs.443277 |
0.50 |
0.10 |
| HSI053H02 |
UBE2C |
Ubiquitin-conjugating enzyme E2C |
Hs.93002 |
0.52 |
0.10 |
| HSI096C06 |
MAPT |
Microtubule-associated protein tau |
Hs.101174 |
0.52 |
0.00 |
| HSI049A02 |
ERGIC1 |
ER-golgi intermediate compartment 1 |
Hs.509163 |
0.53 |
0.09 |
| HSI040C08 |
AZGP1 |
Alpha-2-glycoprotein 1, zinc |
Hs.546239 |
0.55 |
0.00 |
| HSI133F06 |
EST |
Transcribed locus |
Hs.159264 |
0.55 |
0.00 |
| HSI182E08 |
PLAT |
Plasminogen activator, tissue |
Hs.491582 |
0.55 |
0.00 |
| HSI033B05 |
LY6E |
Lymphocyte antigen 6 complex, locus E |
Hs.521903 |
0.56 |
0.00 |
| HSI048F12 |
CCND1 |
Cyclin D1 |
Hs.523852 |
0.56 |
0.10 |
| HSI085G12 |
KCNK15 |
Potassium channel, subfamily K, member 15 |
Hs.528664 |
0.57 |
0.00 |
| HSI177H07 |
PCBP3 |
Poly(rC) binding protein 3 |
Hs.474049 |
0.57 |
0.10 |
| HSI032D02 |
ABCA3 |
ATP-binding cassette, subfamily A3 (ABC1) |
Hs.26630 |
0.57 |
0.00 |
| HSI182A02 |
TFF3 |
Trefoil factor 3 (intestinal) |
Hs.82961 |
0.58 |
0.04 |
| HSI025A03 |
FGD3 |
FYVE, RhoGEF and PH domain containing 3 |
Hs.411081 |
0.58 |
0.00 |
| HSI070B06 |
AP1S1 |
Adaptor-related protein complex 1, sigma 1 subunit |
Hs.489365 |
0.58 |
0.08 |
| HSI057H12 |
GNB2 |
Guanine nucleotide binding protein beta 2 |
Hs.185172 |
0.58 |
0.00 |
| HSI080H11 |
SEMA3F |
Semaphorin 3F |
Hs.32981 |
0.59 |
0.00 |
| HSI054G06 |
NUSAP1 |
Nucleolar and spindle associated protein 1 |
Hs.511093 |
0.59 |
0.00 |
| HSI124D07 |
RIMS4 |
Regulating synaptic membrane exocytosis 4 |
Hs.517065 |
0.59 |
0.00 |
| HSI065C09 |
CNNM2 |
Cyclin M2 |
Hs.500903 |
0.59 |
0.00 |
| HSI080F02 |
PREX1 |
PIP3-dependent RAC exchanger 1 |
Hs.153310 |
0.59 |
0.00 |
| HSI095H09 |
C6orf97 |
Chromosome 6 open reading frame 97 |
Hs.130239 |
0.59 |
0.00 |
| HSI161G02 |
EST |
Transcribed locus |
Hs.570637 |
0.60 |
0.00 |
| HSI045G02 |
UBE2T |
Ubiquitin-conjugating enzyme E2T (putative) |
Hs.5199 |
0.60 |
0.00 |
| HSI046F10 |
TOP2A |
Topoisomerase (DNA) II alpha 170 kDa |
Hs.156346 |
0.60 |
0.00 |
| HSI183D04 |
AR |
Androgen receptor |
Hs.496240 |
0.61 |
0.01 |
| HSI183A08 |
SLC9A3R1 |
Solute carrier family 9, member 3 regulator 1 |
Hs.396783 |
0.61 |
0.00 |
| HSI025G02 |
SHARPIN |
SHANK-associated RH domain interactor |
Hs.529755 |
0.61 |
0.08 |
|
Shown are the first 40 downregulated genes from a paired SAM analysis, which identified 1,264 genes to be downregulated by aromatase inhibitor (AI) treatment below a local false discovery rate of 1% (LFDR). The genes are ranked according to their fold change. | |||||
Mackay et al. Breast Cancer Research 2007 9:R37 doi:10.1186/bcr1732 |
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