Breast Cancer Research
Volume 9
Issue 4 |
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This article is part of a series on
Inflammation and breast cancer, edited by
Mina J Bissell and Jeffrey W Pollard.
ReviewInflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic miceRaffaele Adolfo Calogero, Francesca Cordero, Guido Forni  and Federica Cavallo Molecular Biotechnology Center, Department of Clinical and Biological Sciences, Via Nizza 52, 10126 Turin, Italy  author email corresponding author email
Breast Cancer Research 2007,
9:211doi:10.1186/bcr1745
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10 August 2007 |
Abstract
This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1β, tumour necrosis factor, interferon-γ, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer. | 
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