Breast Cancer Research
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ViewpointEstrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stageHeather L LaMarca  and Jeffrey M Rosen  Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA  author email corresponding author email
Breast Cancer Research 2007,
9:304doi:10.1186/bcr1740 Abstract
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression. | 
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