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Amping up estrogen receptors in breast cancer
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* Corresponding author: Elaine T Alarid alarid@oncology.wisc.edu
Department of Oncology, University of Wisconsin-Madison, Madison, WI 53706, USA
Breast Cancer Research 2007, 9:305 doi:10.1186/bcr1748
Published: 16 August 2007Abstract
This article highlights a recent study by Holst et al. in Nature Genetics that finds estrogen receptor-alpha (ER-α) amplification in early benign lesions and more advanced invasive carcinomas of the breast, and discusses the potential implications to our present understanding of the role of ER-α in breast tumorigenesis.