Table 1 |
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Laboratory methods for assay of bone-turnover markers, lipids, and estrogens |
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| Parameter |
Method |
Manufacturer |
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|
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| Bone resorption |
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| Adjusted U-CTx |
Enzyme immunoassay test using the CrossLaps® ELISA kit |
Nordic Bioscience Diagnostics A/S, Herlev, Denmark |
| S-CTx |
Electrochemoluminescence immunoassay technique using Elecsys 2010 automate analyzer |
Roche Diagnostics, Basel Switzerland |
| Adjusted U-NTx |
Competitive immunoassay technique using the NTx reagent pack kit |
Ortho-Clinical Diagnostics, Amersham, UK |
| Bone formation |
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| BAP |
Ostase Assay using Access Immunoassay System |
Beckman Coulter, Villepinte, France |
| PINP |
Electrochemoluminescence immunoassay technique using Elecsys 2010 automate analyzer |
Roche Diagnostics |
| Lipids (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) |
Validated HPLC–RIA technique using Bayer Advia Reagent Packs. Assayed on an ADVIA® 1650 chemistry system analyzer |
Bayer Diagnostics, Bayer Inc., Tarrytown, NY, USA |
| Estrogen (E1, E2, and E1S) |
Validated HPLC–RIA technique |
Aster-Cephac, Paris, France |
|
|
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BAP, bone alkaline phosphatase; E1, estrone; E1S, estrone sulfate; E2, estradiol; ELISA, enzyme-linked immunosorbent assay; HDL, high-density lipoprotein; HPLC–RIA, high-performance liquid chromatography radioimmunoassay; LDL, low-density lipoprotein; PINP, procollagen type I N-terminal propeptide; S-CTx, serum C-terminal telopeptide of type I collagen; U-CTx, urine-adjusted urinary C-terminal telopeptide of type I collagen; U-NTx, urine-adjusted urinary N-terminal telopeptide of type I collagen. |
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Goss et al. Breast Cancer Research 2007 9:R52 doi:10.1186/bcr1757 |
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