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Median values and median percentage change from baseline for plasma concentrations of estrogens (mITT population) |
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| Estrogen |
Exemestane (n = 20) |
Letrozole (n = 20) |
Anastrozole (n = 18) |
Placebo (n = 20) |
|
|
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| E1 |
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| Baseline, median (min., max.) |
31 (11, 72) |
28 (13, 51) |
29 (14, 61) |
26 (9.9, 61) |
| Week 12, median (min., max.) |
2.0 (1.8, 10) |
1.8 (1.8, 20) |
1.8 (1.8, 84) |
31 (8.4, 58) |
| % baseline, median (95% CI*) |
7.8 (6.9, 9.3) |
6.6 (5.5, 8.1) |
7.6 (6.4, 11) |
101 (89, 110) |
| Week 24, median (min., max.) |
1.8 (1.8, 63) |
1.8 (1.8, 33) |
1.8 (1.8, 44) |
26 (7.2, 56) |
| % baseline, median (95% CI) |
6.7 (5.3, 8.6) |
6.6 (5.1, 8.1) |
7.9 (7.1, 11) |
94 (76, 108) |
| Week 36, median (min., max.) |
23 (10, 62) |
19 (10, 44) |
25 (8.4, 158) |
22 (13, 46) |
| % baseline, median (95% CI) |
72 (63, 86) |
76 (61, 93) |
70 (66, 121) |
89 (72, 95) |
| E2 |
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| Baseline, median (min., max.) |
4.4 (1.1, 13) |
4.2 (1.8, 8.6) |
3.8 (1.9, 32) |
3.9 (1.9, 8.8) |
| Week 12, median (min., max.) |
0.70 (0.70, 2.5) |
0.70 (0.70, 2.7) |
0.70 (0.70, 104) |
3.8 (1.6, 15) |
| % baseline, median (95% CI) |
18 (14, 22) |
19 (14, 24) |
20 (18, 31) |
102 (87, 115) |
| Week 24, median (min., max.) |
0.70 (0.70, 29) |
0.70 (0.70, 7.3) |
0.72 (0.70, 84) |
4.4 (1.9, 12) |
| % baseline, median (95% CI) |
19 (13, 22) |
18 (13, 24) |
22 (19, 31) |
128 (95, 139) |
| Week 36, median (min., max.) |
4.5 (1.6, 36) |
4.2 (1.9, 15) |
4.2 (1.4, 136) |
4.0 (1.6, 11) |
| % baseline, median (95% CI) |
103 (89, 134) |
109 (81, 119) |
106 (92, 130) |
105 (90, 130) |
| E1S |
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| Baseline, median (min., max.) |
192 (58, 757) |
193 (79, 1075) |
202 (64, 896) |
200 (62, 1156) |
| Week 12, median (min., max.) |
13 (8.7, 246) |
8.7 (6.0, 62) |
15 (6.6, 3260) |
209 (58, 876) |
| % baseline, median (95% CI) |
9.1 (6.1, 11) |
4.5 (3.3, 6.0) |
11 (6.7, 13) |
110 (91, 146) |
| Week 24, median (min., max.) |
16 (6.1, 839) |
10 (6.0, 254) |
18 (8.8, 1440) |
195 (64, 802) |
| % baseline, median (95% CI) |
11 (7.2, 13) |
4.7 (3.0, 7.2) |
10 (8.6, 20) |
105 (69, 123) |
| Week 36, median (min., max.) |
223 (7.4, 2100) |
222 (115, 932) |
296 (58, 4890) |
205 (68, 864) |
| % baseline, median (95% CI) |
114 (90, 152) |
121 (105, 135) |
131 (109, 147) |
125 (91, 143) |
|
*95% CI, bias-corrected and adjusted 95% bootstrap CI for median. CI, confidence interval; E1, estrone; E1S, estrone sulfate; E2, estradiol; max; min; mITT, modified intent to treat. | ||||
Goss et al. Breast Cancer Research 2007 9:R52 doi:10.1186/bcr1757 |
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