Table 5

Median values and median percentage change from baseline for serum lipid profiles (mITT population)
Lipid
 Exemestane (n = 20)
 Letrozole (n = 20)
 Anastrozole (n = 19)
 Placebo (n = 20)
LDL-C (mmol/L)
     Baseline
 4.2
 4.2
 4.2
 3.8
     Week 12, % change
 -11
 -4.5
 -12
 -6.1
     Week 24, % change
 -2.6
 -4.2
 -3.0
 2.4
     Week 36, % change
 1.9
 0.25
 -5.7
 -5.8
HDL-C (mmol/L)
     Baseline, median
 1.4
 1.5
 1.4
 1.4
     Week 12, % change
 -4.4
 9.0
 1.7
 -3.5
     Week 24, % change
 -13
 -2.4
 -4.4
 -6.3
     Week 36, % change
 -6.9
 -2.4
 -2.5
 -6.8
Total cholesterol (mmol/L)
     Baseline, median
 6.1
 6.1
 6.3
 5.9
     Week 12, % change
 -6.8
 -1.8
 -3.7
 -2.6
     Week 24, % change
 0.78
 1.2
 -0.68
 0.75
     Week 36, % change
 1.3
 -1.9
 -5.8
 -6.4
Triglycerides (mmol/L)
     Baseline, median
 1.1
 1.2
 1.2
 1.0
     Week 12, % change
 -21
 6.6
 -10
 -1.6
     Week 24, % change
 1.7
 4.6
 6.3
 -7.0
     Week 36, % change
 -1.1
 -5.4
 -3.5
 -0.28

HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; mITT = modified intent to treat.

Goss et al. Breast Cancer Research 2007 9:R52   doi:10.1186/bcr1757