Table 2

Differentially expressed genes between the young and old cohorts

UniGene symbol

Fold change^a

UniGene name

Genes with higher expression in the young cohort

AREG^b

3.12

Amphiregulin (schwannoma-derived growth factor)

PRSS2^b

2.71

Protease, serine, 2 (trypsin 2)

GREB1^b

2.34

GREB1 protein

PTHLH^b,d

2.01

Parathyroid hormone-like hormone

HPGD^c

1.98

Hydroxyprostaglandin dehydrogenase 15-(NAD)

SPANXA1///SPANXB1///SPANXA2///SPANXC^c///SPANXB2

1.91

Sperm protein associated with the nucleus, X-linked, family member A1///SPANX family, member B1///SPANX family, member A2///SPANX family, member C///SPANX family, member B2

LAMA3^d

1.87

Laminin, alpha 3

ATP6V1B1^c

1.82

ATPase, H⁺ transporting, lysosomal 56/58 kDa, V1 subunit B, isoform 1 (renal tubular acidosis with deafness)

S100A2^b,d

1.79

S100 calcium binding protein A₂

DIO2^c

1.79

Deiodinase, iodothyronine, type II

PRSS1^b///PRSS2^b///PRSS3///TRY6

1.77

Protease, serine, 1 (trypsin 1)///protease, serine, 2 (trypsin 2)///protease, serine, 3 (mesotrypsin)///trypsinogen C

FGFR1^b,d,e

1.65

Fibroblast growth factor receptor 1

TP73L^b,d

1.60

Tumor protein p73-like

PRSS1^b

1.59

Protease, serine, 1 (trypsin 1)

C20orf59

1.57

Chromosome 20 open reading frame 59

DLG7^b,f

1.56

Discs, large homolog 7 (Drosophila)

ELOVL2^c

1.52

Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2

KIF2C^b,f

1.50

Kinesin family member 2C

STK6^b,f

1.49

Serine/threonine kinase 6

UST^c

1.47

Uronyl-2-sulfotransferase

CDC14A^f

1.42

CDC14 cell division cycle 14 homolog A (S. cerevisiae)

ELL3^c

1.42

Elongation factor RNA polymerase II-like 3

RAD54B^c,f

1.41

RAD54 homolog B (S. cerevisiae)

ITGA2^b,d,e

1.33

Integrin, alpha 2 (CD49B, α₂ subunit of VLA-2 receptor)

Genes with higher expression in the old cohort

HOXB6^b,d

2.40

Homeobox B6

TMC5

2.36

Transmembrane channel-like 5

HOXB2^c,d

1.99

Homeobox B2

ST6GALNAC5

1.99

ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5///ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5

KIAA1102

1.82

KIAA1102 protein

PYGL^c

1.82

Phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)

TNFSF10^b

1.82

Tumor necrosis factor (ligand) superfamily, member 10///tumor necrosis factor (ligand) superfamily, member 10

GOLPH2^c

1.78

Golgi phosphoprotein 2

DSPG3^c

1.75

Dermatan sulfate proteoglycan 3

GLRX^c

1.75

Glutaredoxin (thioltransferase)

FLJ20152

1.73

Hypothetical protein FLJ20152

GATM^c

1.72

Glycine amidinotransferase (l-arginine:glycine amidinotransferase)

ENTPD5^b

1.69

Ectonucleoside triphosphate diphosphohydrolase 5

SASH1^b,f

1.69

SAM and SH3 domain containing 1

ITPR1^b

1.68

Inositol 1,4,5-triphosphate receptor, type 1

ANG^c,d,e///RNASE4

1.66

Angiogenin, ribonuclease, RNase A family, 5///ribonuclease, RNase A family, 4

IQGAP2^b

1.63

IQ motif containing GTPase activating protein 2

MANSC1

1.62

MANSC domain containing 1

HOXB5^c,d,e

1.60

Homeobox B5

FAH^b

1.60

Fumarylacetoacetate hydrolase (fumarylacetoacetase)

ARHGDIB^c,d

1.60

Rho GDP dissociation inhibitor (GDI) beta

TAPBPL^c

1.59

TAP binding protein-like

CLMN^c

1.56

Calmin (calponin-like, transmembrane)

ESR1^b,d,e,f

1.56

Estrogen receptor 1

EFNA1^b

1.56

Ephrin-A1

COBLL1

1.56

COBL-like 1

P8^b,d,e

1.55

p8 protein (candidate of metastasis 1)

SC5DL

1.52

Sterol-C5-desaturase (ERG3 δ-5-desaturase homolog, fungal)-like

CLEC5A

1.52

C-type lectin domain family 5, member A

SEPT6^f

1.52

Septin 6

RHOB^b,d,e,f

1.52

Ras homolog gene family, member B

CYB5

1.51

Cytochrome b-5

PDE4A^b

1.50

Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)

C21orf25

1.49

Chromosome 21 open reading frame 25

CCL3^c///CCL3L1///CCL3L3

1.49

Chemokine (C–C motif) ligand 3///chemokine (C–C motif) ligand 3-like 1///chemokine (C–C motif) ligand 3-like 3

CCDC28A

1.46

Coiled-coil domain containing 28A

CALM3

1.46

Calmodulin 3 (phosphorylase kinase, delta)

PPFIBP2^c

1.46

PTPRF interacting protein, binding protein 2 (liprin β2)

DBI^c

1.46

Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)

SLC25A12^c

1.45

Solute carrier family 25 (mitochondrial carrier, Aralar), member 12

CPM^b,d,e

1.44

Carboxypeptidase M

MARCH8

1.43

Membrane-associated ring finger (C3HC4) 8

FLJ20298

1.41

FLJ20298 protein

SLC12A8^c

1.40

Solute carrier family 12 (potassium/chloride transporters), member 8

FUCA1^b

1.39

Fucosidase, alpha-L-1, tissue

LOC57146

1.38

Promethin

RANBP2^c

1.36

RAN binding protein 2

HOXB7^b,d

1.36

Homeobox B7

PANX1^c

1.33

Pannexin 1

TGOLN2^b

1.31

trans-Golgi network protein 2

VWA1^c

1.29

von Willebrand factor A domain containing 1

^aYoung/old for genes with higher expression in the young cohort; old/young for genes with higher expression in the old cohort. ^bGenes showing first-degree association with cancer and ^cgenes showing second-degree association with cancer (associations as determined through MEDGENE database searches with terms Carcinoma, Ductal Breast Carcinoma, Neoplasms and Breast Neoplasms). ^dGenes involved in 'development', ^egenes involved in morphogenesis and ^fgenes involved in the cell cycle, as functionally annotated by the DAVID database and contributed to the enrichment probability calculations – these three major gene ontology biological processes were found to be enriched among the 75 differentially expressed genes. Enrichment was defined as Expression Analysis Systematic Explorer score < 0.05.

Yau et al. Breast Cancer Research 2007 9:R59   doi:10.1186/bcr1765