Figure 5.

Model for BP1-mediated disruption of caspase activation after TNFα treatment. Arrows indicate the three points (a, b and c) at which Beta Protein 1 (BP1) may impact apoptosis. Bid, BH3 interacting domain death agonist; CYT C, cytochrome c; FADD, Fas (TNFRSF6)-associated via death domain; PARP, Poly(ADP-Ribose) Polymerase; t-Bid, truncated Bid; TNFR1, TNF receptor 1; TRADD, TNFRSF1A-associated via death domain.