Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

Petra EA Huijts1*, Maaike PG Vreeswijk2, Karin HG Kroeze-Jansema2, Catharina E Jacobi3, Caroline Seynaeve4, Elly MM Krol-Warmerdam5, Pauline M Wijers-Koster6, Jannet C Blom4, Karen A Pooley7, Jan GM Klijn4, Rob AEM Tollenaar5, Peter Devilee2,6 and Christi J van Asperen1

Author Affiliations

1 Department of Clinical Genetics, K5-R, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

2 Department of Human Genetics, S4-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

3 Department of Medical Decision Making, J10-S, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

4 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC–Daniel den Hoed Cancer Center, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands

5 Department of Surgery, K6-R, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

6 Department of Pathology, L1-Q, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

7 Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN UK

For all author emails, please log on.

Breast Cancer Research 2007, 9:R78 doi:10.1186/bcr1793

Published: 12 November 2007

Additional files

Additional file 1:

A pdf file containing a table that presents the combined odds ratios for rs2981582 and for each of the other investigated SNPs in the ORIGO cohort. The combined effect on the breast cancer risk of SNP rs2981582 and each of the other six SNPs was explored pairwise. The observed odds ratios and their 95% confidence intervals are presented in this additional file.

Format: PDF Size: 58KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

A pdf file containing a table that presents the associations of each of the seven investigated SNPs with disease characteristics and patient characteristics in the ORIGO cohort.

Format: PDF Size: 102KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data