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Combined odds ratios for the two most significant SNPs in the Dutch hospital-based ORIGO cohort of breast cancer patients |
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| SNP rs2981582 in FGFR2 |
SNP rs3803662 near TNRC9 |
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| 0 (wt/wt) |
1 (wt/mt) |
2 (mt/mt) |
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| 0 (wt/wt) |
1.00 |
1.25 (0.87–1.78) |
1.12 (0.64–1.97) |
| 1 (wt/mt) |
1.28 (0.95–1.72) |
1.48 (1.06–2.05) |
1.90 (1.07–3.39) |
| 2 (mt/mt) |
1.76 (1.17–2.66) |
2.22 (1.37–3.60) |
1.35 (0.57–3.20) |
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The combined effect of SNPs rs2981582 and rs3803662 on breast cancer risk was studied in the ORIGO cohort. The observed odds ratios and their 95% confidence intervals are presented. wt/wt, patients homozygous for the wildtype allele; wt/mt, patients heterozygous for the wildtype and mutated or minor allele; mt/mt, patients homozygous for the mutated or minor allele. P value for overall differences = 0.022. | |||
Huijts et al. Breast Cancer Research 2007 9:R78 doi:10.1186/bcr1793 |
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