Table 3 |
||||||||
|
Odds ratios and 95% confidence intervals for breast cancer risk associated with BsmI and Poly(A) genotypes, stratified by race and menopausal status |
||||||||
|
Genotype |
Menopausal status |
Caucasian |
African-American |
|||||
|
Case (%) |
Control (%) |
ORa (95% CI) |
Case (%) |
Control (%) |
ORa (95% CI) |
|||
|
|
||||||||
|
BsmI |
B/B |
Premenopausal |
164 (25.3) |
133 (25.8) |
1.0 (referent) |
38 (12.1) |
22 (9.6) |
1.0 (referent) |
|
B/b |
244 (36.9) |
198 (36.0) |
1.1 (0.8 to 1.5) |
108 (34.6) |
90 (36.7) |
0.8 (0.4 to 1.4) |
||
|
b/b |
247 (37.8) |
199 (38.1) |
1.0 (0.7 to 1.4) |
156 (53.3) |
126 (53.7) |
0.8 (0.4 to 1.5) |
||
|
Any b |
491 (74.7) |
397 (74.2) |
1.0 (0.8 to 1.4) |
264 (87.9) |
216 (90.4) |
0.8 (0.4 to 1.4) |
||
|
B/B |
Postmenopausal |
114 (23.5) |
125 (29.2) |
1.0 (referent) |
29 (15.2) |
28 (14.3) |
1.0 (referent) |
|
|
B/b |
188 (39.3) |
173 (40.9) |
1.2 (0.8 to 1.8) |
66 (38.0) |
78 (34.0) |
1.0 (0.5 to 2.0) |
||
|
b/b |
179 (37.2) |
137 (30.0) |
1.5 (1.0 to 2.3)b |
88 (46.8) |
102 (51.7) |
0.9 (0.5 to 2.0) |
||
|
Any b |
367 (76.5) |
310 (70.8) |
1.4 (1.0 to 1.9) |
154 (84.8) |
180 (85.7) |
1.0 (0.5 to 1.8) |
||
|
Poly(A) |
S/S |
Premenopausal |
98 (15.7) |
79 (15.4) |
1.0 (referent) |
23 (9.1) |
14 (6.8) |
1.0 (referent) |
|
L/S |
303 (45.3) |
260 (47.3) |
0.9 (0.6 to 1.4) |
109 (39.6) |
88 (39.2) |
0.8 (0.4 to 1.7) |
||
|
L/L |
256 (39) |
203 (37.3) |
1.0 (0.7 to 1.5) |
144 (51.3) |
118 (54.1) |
0.7 (0.3 to 1.6) |
||
|
Any L |
559 (84.3) |
463 (84.6) |
1.0 (0.7 to 1.4) |
253 (90.9) |
206 (93.3) |
0.7 (0.4 to 1.6) |
||
|
S/S |
Postmenopausal |
69 (14.5) |
70 (15.8) |
1.0 (referent) |
12 (8.5) |
13 (6.8) |
1.0 (referent) |
|
|
L/S |
229 (47.2) |
222 (52.2) |
1.0 (0.7 to 1.6) |
72 (41.9) |
81 (38.9) |
0.8 (0.3 to 2.1) |
||
|
L/L |
184 (38.3) |
151 (31.9) |
1.3 (0.9 to 2.1) |
81 (49.5) |
103 (54.3) |
0.8 (0.3 to 2.1) |
||
|
Any L |
413 (85.5) |
373 (84.2) |
1.2 (0.8 to 1.8) |
153 (91.5) |
184 (93.2) |
0.8 (0.3 to 2.0) |
||
|
|
||||||||
|
aOdds ratio (OR) adjusted for age, race, study site, and sampling weights. bP for trend <0.05. |
||||||||
|
Trabert et al. Breast Cancer Research 2007 9:R84 doi:10.1186/bcr1833 |
||||||||
