Breast Cancer Research

official impact factor 5.79

Open Access Research article

CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer

Francisco J Esteva1*, Jing Wang2, Feng Lin2, Jaime A Mejia1, Kai Yan2, Kadri Altundag1,3, Vicente Valero1, Aman U Buzdar1, Gabriel N Hortobagyi1, W Fraser Symmans4 and Lajos Pusztai1

Author Affiliations

1 Department of Breast Medical Oncology, Unit 1354, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA

2 Department of Bioinformatics and Computational Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA

3 Department of Medical Oncology, Hacettepe University Institute of Oncology, Sihhiye St, Ankara 06100, Turkey

4 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA

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Breast Cancer Research 2007, 9:R87 doi:10.1186/bcr1836

Published: 17 December 2007

Additional files

Additional file 1:

Revised intrinsic gene set table.

Format: XLS Size: 642KB Download file

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Additional file 2:

Table of 63 genes featuring the CD40 signaling pathway

Format: XLS Size: 40KB Download file

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Additional file 3:

Complete results from the GSEA

Format: XLS Size: 689KB Download file

This file can be viewed with: Microsoft Excel Viewer

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