Figure 1.

Association between pathologic complete response (pCR) and HER-2, estrogen receptor (ER), and Ki-67 mRNA levels and HER-2 gene copy number ratio shown by fluorescence in situ hybridization (FISH). Association between pCR and (a) the mRNA expression levels of HER-2 (Spearman's rank correlation = 0.087; P = 0.69), (b) ER (Spearman's rank correlation = -0.052; P = 0.81), and (c) Ki-67 (Wilcoxon rank sum = 148; P = 0.2) or (d) the level of HER-2 gene amplification shown by FISH (Wilcoxon rank sum = -0.45; P = 0.65). Each circle represents results from one case and has been grouped by response category (pCR or RD [residual disease]).