Figure 3.

CD40 pathway gene set significantly enriched in patient's pathologic complete response and residual disease phenotypes. (a) Plot of the running sum for CD40 pathway gene set in the expression data set. (b) Plot of null bimodal ES distributions (c) Heat map produced using expression data from CD40 pathway gene set, and sorted by pCR and RD phenotypes. ES: enrichment score; FDR: false discovery rate; FWER: family wise error rate; NES: normalized enrichment score; pCR: pathologic complete response; RD: residual disease.