Table 2 |
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|
Mammary tumor incidence, latency, and weight and number for MMTV TGF-α mice |
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| Overall mammary tumor incidence (percentage) |
Palpable mammary tumor incidence (percentage) |
Palpable mammary tumor latency, weeks |
Mammary tumor weight, gramsa |
Mammary tumor numbera |
|
|
|
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| Obesity-Prone |
26/30 (79)b,c |
18/33 (55)d |
74.1 ± 2.4e |
2.407 ± 0.32f |
3.9 ± 0.08 |
| Obesity-Resistant |
12/17 (71) |
5/29 (29) |
76.7 ± 2.1 |
1.298 ± 0.35g |
3.5 ± 0.20 |
| Low-Fat |
11/20 (55) |
2/20 (10) |
81.9 ± 0.1 |
0.653 ± 0.29g |
2.3 ± 0.18 |
|
|
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|
aValues from tumor-bearing mice only: Obesity-Prone (n = 26), Obesity-Resistant (n = 12), and Low-Fat (n = 11). Analysis of variance for statistical comparison. bChi-square p = 0.07 among the groups; Obesity-Prone versus Low-Fat, p = 0.06. cLow-grade adenocarcinomas confirmed by histopathology except for six high-grade adenocarcinomas in six different Obesity-Prone mice. dChi-square p = 0.0038 among the groups; Obesity-Prone versus Low-Fat, p = 0.0012; Obesity-Prone versus Obesity-Resistant, p = 0.09; Obesity-Resistant versus Low-Fat, p = 0.21. eDifferences among groups significant by log-rank test, p = 0.0015. This was followed by proportional hazard model: Obesity-Prone versus Low-Fat, p = 0.0041, and Obesity-Resistant versus Low-Fat, p = not significant. Different superscripts (f and g) indicate significant difference. |
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|
Dogan et al. Breast Cancer Research 2007 9:R91 doi:10.1186/bcr1840 |
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