Table 3 |
||||
|
Summary of diet effects on leptin and apoptosis signaling protein and mRNA expression levels |
||||
|
MT |
MFP |
|||
|
|
||||
|
Leptin signaling molecules |
||||
|
Leptin |
NC |
|
NC |
NC |
|
ObR |
NC |
|
NC |
|
|
ObRb |
|
|
|
|
|
Jak2 |
|
NM |
|
NM |
|
pSTAT3 |
|
|
NC |
NC |
|
Apoptosis signaling molecules |
||||
|
PARP (total) |
|
|
||
|
PARP (89 kDa) |
|
NC |
||
|
PARP (24 kDa) |
|
NC |
||
|
Caspase-3 activity |
|
|
||
|
Bax |
NC |
|
||
|
Bcl-2 |
NC |
NC |
||
|
Bcl-XL |
|
|
||
|
pAkt |
NC |
NC |
||
|
|
||||
|
Jak2, Janus kinase 2; MFP, mammary fat pad; MT, mammary tumor; NC, no statistically significant change; NM, not measured; pAkt, phosphorylated Akt; PARP, poly(ADP-ribose)polymerase; pSTAT3, phosphorylated signal transducer and activator of transcription 3. Solid arrows show protein expression and dashed lines mRNA expression. |
||||
|
Dogan et al. Breast Cancer Research 2007 9:R91 doi:10.1186/bcr1840 |
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