Dominance and nondominance of the radial scar/complex sclerosing lesion and associated pathology

bcr1423 BCJ Oral Presentation Dominance and nondominance of the radial scar/complex sclerosing lesion and associated pathology Birchley D Steel JR Jones PA Holgate CS Watkins RM

Derriford Hospital, Plymouth, UK

Breast Cancer Research Symposium Mammographicum 2006 Meeting abstracts http://breast-cancer-research.com/content/pdf/bcr1423.pdf Symposium Mammographicum 2006 Bournemouth, UK

9–11 July 2006

http://www.sympmamm.org.uk/ 1465-5411 2006 8 Suppl 1 P8 10.1186/bcr1423 10 7 2006

Aim

To establish whether there is a significant difference in the pathology associated with radial scars (RS) or complex sclerosing lesions (CSL).

Patients and methods

RS or CSL were recorded in 178 specimens over a 17-year period. Three associated pathologies were noted – atypical hyperplasia, in situ malignancy and invasive carcinoma. The sclerosing lesions were categorised as to whether the RS/CSL was dominant (i.e. larger than the associated pathology) or nondominant (smaller than the associated pathology).

Results

Sixty-four patients (36%) had RS/CSL with associated pathology: atypical hyperplasia (17), in situ (24) or invasive (23) malignancy. There was a significant (P < 0.001, chi-square 17.5) difference in proportions for histological types between lesions where the RS/CSL was dominant and lesions where they were not. Lesions with a dominant RS/CSL were associated with significantly more in situ malignancy and atypical hyperplasia. Invasive carcinoma was associated with nondominant RS/CSL.

Conclusion

The nature of the associated pathology appears to be related to the dominance or nondominance of the RS/CSL.

Table 1

RS/CSL dominant

Yes

Total

Associated pathology

ADH/ALH

In situ

Invasive

Total