Breast Cancer Research | Volume 15 Issue 2

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	Volume 15 Issue 2
	Comment
	Editorial It takes two to tango in the microenvironment! Josie Ursini-Siegel, Morag Park Breast Cancer Research 2013, 15:102 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Metformin: a case of divide and conquer Dimitrios Anastasiou Breast Cancer Research 2013, 15:306 (11 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Elf5 - breast cancer's little helper Hayley T Frend, Christine J Watson Breast Cancer Research 2013, 15:307 (27 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors Ashish Juvekar, Gerburg M Wulf Breast Cancer Research 2013, 15:308 (8 April 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression Swarnali Acharyya Breast Cancer Research 2013, 15:309 (23 April 2013) Abstract \| Full text \| PDF \| PubMed
	Review
	Review The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy Mun Hui, Aurélie Cazet, Radhika Nair, D Watkins, Sandra A O'Toole, Alexander Swarbrick Breast Cancer Research 2013, 15:203 (28 March 2013) Abstract \| Full text \| PDF \| PubMed
	Review The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker Michael L Salmans, Fang Zhao, Bogi Andersen Breast Cancer Research 2013, 15:204 (24 April 2013) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancer John FR Robertson, J Michael Dixon, D Mark Sibbering, Ali Jahan, Ian O Ellis, Eddie Channon, Pauline Hyman-Taylor, Robert I Nicholson, Julia MW Gee Breast Cancer Research 2013, 15:R18 (5 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II Renée T Fortner, A Heather Eliassen, Donna Spiegelman, Walter C Willett, Robert L Barbieri, Susan E Hankinson Breast Cancer Research 2013, 15:R19 (6 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Comparison of three molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer Areti Strati, Sabine Kasimir-Bauer, Athina Markou, Cleo Parisi, Evi S Lianidou Breast Cancer Research 2013, 15:R20 (7 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling Hannah Harrison, Bruno M Simões, Lynsey Rogerson, Sacha J Howell, Göran Landberg, Robert B Clarke Breast Cancer Research 2013, 15:R21 (8 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer Marc-André Déry, Julie Jodoin, Josie Ursini-Siegel, Olga Aleynikova, Cristiano Ferrario, Saima Hassan, Mark Basik, Andréa C LeBlanc Breast Cancer Research 2013, 15:R22 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer Xuedong Yin, Tingxiu Xiang, LiLi Li, Xianwei Su, Xingsheng Shu, Xinrong Luo, Jianbo Huang, Ying Yuan, Weiyan Peng, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao Breast Cancer Research 2013, 15:R23 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease Laurel A Habel, Lori C Sakoda, Ninah Achacoso, Xiao-Jun Ma, Mark G Erlander, Dennis C Sgroi, Louis Fehrenbacher, Deborah Greenberg, Charles P Quesenberry Breast Cancer Research 2013, 15:R24 (14 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Embryonic mammary signature subsets are activated in Brca1^-/-and basal-like breast cancers Marketa Zvelebil, Erik Oliemuller, Qiong Gao, Olivia Wansbury, Alan Mackay, Howard Kendrick, Matthew J Smalley, Jorge S Reis-Filho, Beatrice A Howard Breast Cancer Research 2013, 15:R25 (18 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer Sepideh Gholami, Chun-Hao Chen, Laurence J Belin, Emil Lou, Sho Fujisawa, Caroline Antonacci, Amanda Carew, Nanhai G Chen, Marina De Brot, Pat B Zanzonico, Aladar A Szalay, Yuman Fong Breast Cancer Research 2013, 15:R26 (18 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Oncolytic vaccinia virus, GLV1h-153, engineered to express the human sodium iodide symporter (hNIS) gene is useful in imaging cancers and can be used to identify and treat positive surgical margins of breast cancer in mice.
	Research article Risk of breast cancer in Lynch syndrome: a systematic review Aung Win, Noralane M Lindor, Mark A Jenkins Breast Cancer Research 2013, 15:R27 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer Benjamin A Katchman, I Tolgay Ocal, Heather E Cunliffe, Yu-Hui Chang, Galen Hostetter, Aprill Watanabe, Janine LoBello, Douglas F Lake Breast Cancer Research 2013, 15:R28 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer Rita D Brandão, Jürgen Veeck, Koen K Van de Vijver, Patrick Lindsey, Bart de Vries, Catharina HMJ van Elssen, Marinus J Blok, Kristien Keymeulen, Torik Ayoubi, Hubert JM Smeets, Vivianne C Tjan-Heijnen, Pierre S Hupperets Breast Cancer Research 2013, 15:R29 (8 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A randomized controlled trial finds that celecoxib, a COX-2 inhibitor, induces anti-tumor transcriptional changes in primary breast cancer tissue, suggesting a use for celecoxib in future treatments.
	Research article HIF-1α stimulates aromatase expression driven by prostaglandin E₂in breast adipose stroma Nirukshi U Samarajeewa, Fangyuan Yang, Maria M Docanto, Minako Sakurai, Keely M McNamara, Hironobu Sasano, Stephen B Fox, Evan R Simpson, Kristy A Brown Breast Cancer Research 2013, 15:R30 (8 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Is TIMP-1 immunoreactivity alone or in combination with other markers a predictor of benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial? Alison F Munro, Annette Bartels, Eva Balslev, Christopher J Twelves, David A Cameron, Nils Brünner, John MS Bartlett Breast Cancer Research 2013, 15:R31 (9 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling Lopamudra Roy, Jennifer M Curry, Mahnaz Sahraei, Dahlia M Besmer, Amritha Kidiyoor, Helen E Gruber, Pinku Mukherjee Breast Cancer Research 2013, 15:R32 (11 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mouse model of rheumatoid arthritis shows that SCF/c-Kit signalling mast cells accumulate in bone and lung metastatic niches, which enhances breast cancer metastasis.
	Research article miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs Muhammad Riaz, Marijn TM van Jaarsveld, Antoinette Hollestelle, Wendy JC Prager-van der Smissen, Anouk AJ Heine, Antonius WM Boersma, Jingjing Liu, Jean Helmijr, Bahar Ozturk, Marcel Smid, Erik A Wiemer, John A Foekens, John WM Martens Breast Cancer Research 2013, 15:R33 (19 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: a nested case-control study Roni T Falk, Louise A Brinton, Joanne F Dorgan, Barbara J Fuhrman, Timothy D Veenstra, Xia Xu, Gretchen L Gierach Breast Cancer Research 2013, 15:R34 (22 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience Paul M Meaney, Peter A Kaufman, Lori S Muffly, Michael Click, Stephen P Poplack, Wendy A Wells, Gary N Schwartz, Roberta M di Florio-Alexander, Tor D Tosteson, Zhongze Li, Shireen D Geimer, Margaret W Fanning, Tian Zhou, Neil R Epstein, Keith D Paulsen Breast Cancer Research 2013, 15:R35 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microwave imaging may provide a low cost alternative to magnetic resonance and positron emission tomography for monitoring patient response to neoadjuvant chemotherapy (NCT).
	Research article Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen, Mohamed Bentires-Alj Breast Cancer Research 2013, 15:R36 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.

	Volume 15 Issue 2
	Comment
	Editorial It takes two to tango in the microenvironment! Josie Ursini-Siegel, Morag Park Breast Cancer Research 2013, 15:102 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Metformin: a case of divide and conquer Dimitrios Anastasiou Breast Cancer Research 2013, 15:306 (11 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Elf5 - breast cancer's little helper Hayley T Frend, Christine J Watson Breast Cancer Research 2013, 15:307 (27 March 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors Ashish Juvekar, Gerburg M Wulf Breast Cancer Research 2013, 15:308 (8 April 2013) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression Swarnali Acharyya Breast Cancer Research 2013, 15:309 (23 April 2013) Abstract \| Full text \| PDF \| PubMed
	Review
	Review The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy Mun Hui, Aurélie Cazet, Radhika Nair, D Watkins, Sandra A O'Toole, Alexander Swarbrick Breast Cancer Research 2013, 15:203 (28 March 2013) Abstract \| Full text \| PDF \| PubMed
	Review The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker Michael L Salmans, Fang Zhao, Bogi Andersen Breast Cancer Research 2013, 15:204 (24 April 2013) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancer John FR Robertson, J Michael Dixon, D Mark Sibbering, Ali Jahan, Ian O Ellis, Eddie Channon, Pauline Hyman-Taylor, Robert I Nicholson, Julia MW Gee Breast Cancer Research 2013, 15:R18 (5 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II Renée T Fortner, A Heather Eliassen, Donna Spiegelman, Walter C Willett, Robert L Barbieri, Susan E Hankinson Breast Cancer Research 2013, 15:R19 (6 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Comparison of three molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer Areti Strati, Sabine Kasimir-Bauer, Athina Markou, Cleo Parisi, Evi S Lianidou Breast Cancer Research 2013, 15:R20 (7 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling Hannah Harrison, Bruno M Simões, Lynsey Rogerson, Sacha J Howell, Göran Landberg, Robert B Clarke Breast Cancer Research 2013, 15:R21 (8 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer Marc-André Déry, Julie Jodoin, Josie Ursini-Siegel, Olga Aleynikova, Cristiano Ferrario, Saima Hassan, Mark Basik, Andréa C LeBlanc Breast Cancer Research 2013, 15:R22 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer Xuedong Yin, Tingxiu Xiang, LiLi Li, Xianwei Su, Xingsheng Shu, Xinrong Luo, Jianbo Huang, Ying Yuan, Weiyan Peng, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao Breast Cancer Research 2013, 15:R23 (12 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease Laurel A Habel, Lori C Sakoda, Ninah Achacoso, Xiao-Jun Ma, Mark G Erlander, Dennis C Sgroi, Louis Fehrenbacher, Deborah Greenberg, Charles P Quesenberry Breast Cancer Research 2013, 15:R24 (14 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Embryonic mammary signature subsets are activated in Brca1^-/-and basal-like breast cancers Marketa Zvelebil, Erik Oliemuller, Qiong Gao, Olivia Wansbury, Alan Mackay, Howard Kendrick, Matthew J Smalley, Jorge S Reis-Filho, Beatrice A Howard Breast Cancer Research 2013, 15:R25 (18 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer Sepideh Gholami, Chun-Hao Chen, Laurence J Belin, Emil Lou, Sho Fujisawa, Caroline Antonacci, Amanda Carew, Nanhai G Chen, Marina De Brot, Pat B Zanzonico, Aladar A Szalay, Yuman Fong Breast Cancer Research 2013, 15:R26 (18 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Oncolytic vaccinia virus, GLV1h-153, engineered to express the human sodium iodide symporter (hNIS) gene is useful in imaging cancers and can be used to identify and treat positive surgical margins of breast cancer in mice.
	Research article Risk of breast cancer in Lynch syndrome: a systematic review Aung Win, Noralane M Lindor, Mark A Jenkins Breast Cancer Research 2013, 15:R27 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
	Research article Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer Benjamin A Katchman, I Tolgay Ocal, Heather E Cunliffe, Yu-Hui Chang, Galen Hostetter, Aprill Watanabe, Janine LoBello, Douglas F Lake Breast Cancer Research 2013, 15:R28 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer Rita D Brandão, Jürgen Veeck, Koen K Van de Vijver, Patrick Lindsey, Bart de Vries, Catharina HMJ van Elssen, Marinus J Blok, Kristien Keymeulen, Torik Ayoubi, Hubert JM Smeets, Vivianne C Tjan-Heijnen, Pierre S Hupperets Breast Cancer Research 2013, 15:R29 (8 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A randomized controlled trial finds that celecoxib, a COX-2 inhibitor, induces anti-tumor transcriptional changes in primary breast cancer tissue, suggesting a use for celecoxib in future treatments.
	Research article HIF-1α stimulates aromatase expression driven by prostaglandin E₂in breast adipose stroma Nirukshi U Samarajeewa, Fangyuan Yang, Maria M Docanto, Minako Sakurai, Keely M McNamara, Hironobu Sasano, Stephen B Fox, Evan R Simpson, Kristy A Brown Breast Cancer Research 2013, 15:R30 (8 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Is TIMP-1 immunoreactivity alone or in combination with other markers a predictor of benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial? Alison F Munro, Annette Bartels, Eva Balslev, Christopher J Twelves, David A Cameron, Nils Brünner, John MS Bartlett Breast Cancer Research 2013, 15:R31 (9 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling Lopamudra Roy, Jennifer M Curry, Mahnaz Sahraei, Dahlia M Besmer, Amritha Kidiyoor, Helen E Gruber, Pinku Mukherjee Breast Cancer Research 2013, 15:R32 (11 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mouse model of rheumatoid arthritis shows that SCF/c-Kit signalling mast cells accumulate in bone and lung metastatic niches, which enhances breast cancer metastasis.
	Research article miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs Muhammad Riaz, Marijn TM van Jaarsveld, Antoinette Hollestelle, Wendy JC Prager-van der Smissen, Anouk AJ Heine, Antonius WM Boersma, Jingjing Liu, Jean Helmijr, Bahar Ozturk, Marcel Smid, Erik A Wiemer, John A Foekens, John WM Martens Breast Cancer Research 2013, 15:R33 (19 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: a nested case-control study Roni T Falk, Louise A Brinton, Joanne F Dorgan, Barbara J Fuhrman, Timothy D Veenstra, Xia Xu, Gretchen L Gierach Breast Cancer Research 2013, 15:R34 (22 April 2013) Abstract \| Provisional PDF \| PubMed
	Research article Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience Paul M Meaney, Peter A Kaufman, Lori S Muffly, Michael Click, Stephen P Poplack, Wendy A Wells, Gary N Schwartz, Roberta M di Florio-Alexander, Tor D Tosteson, Zhongze Li, Shireen D Geimer, Margaret W Fanning, Tian Zhou, Neil R Epstein, Keith D Paulsen Breast Cancer Research 2013, 15:R35 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microwave imaging may provide a low cost alternative to magnetic resonance and positron emission tomography for monitoring patient response to neoadjuvant chemotherapy (NCT).
	Research article Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen, Mohamed Bentires-Alj Breast Cancer Research 2013, 15:R36 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.

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Volume 15 Issue 2

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