- Lewis Chodosh, University of Pennsylvania
A novel and simplified molecular and immunohistochemical signature has been described for molecular apocrine breast tumours which could help with easy identification in clinical practice.
Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.
Microwave imaging may provide a low cost alternative to magnetic resonance and positron emission tomography for monitoring patient response to neoadjuvant chemotherapy (NCT).
A mouse model of rheumatoid arthritis shows that SCF/c-Kit signalling mast cells accumulate in bone and lung metastatic niches, which enhances breast cancer metastasis.
A randomized controlled trial finds that celecoxib, a COX-2 inhibitor, induces anti-tumor transcriptional changes in primary breast cancer tissue, suggesting a use for celecoxib in future treatments.
Oncolytic vaccinia virus, GLV1h-153, engineered to express the human sodium iodide symporter (hNIS) gene is useful in imaging cancers and can be used to identify and treat positive surgical margins of breast cancer in mice.
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Aims & scope
Breast Cancer Research is an international, peer-reviewed online journal, publishing original research, reviews, commentaries and reports. Research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition, the journal publishes clinical studies with a biological basis, including Phase I and Phase II trials.
All reviews, commentaries and reports published in Breast Cancer Research become free to access 6 months after publication. See below for the latest free review.
Matteo Lazzeroni, Davide Serrano, Barbara K Dunn, Brandy M Heckman-Stoddard, Oukseub Lee, Seema Khan, Andrea DecensiBreast Cancer Research 2012, 14:214 (29 October 2012)
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