- Lewis Chodosh, University of Pennsylvania
Rots and colleagues describe aberrant DNA methylation and histone modifications as two important classes of epigenetic mutations in breast cancer and review the preclinical and clinical epigenetic-based therapies currently being explored.
An updated pathological definition of breast cancer molecular subtypes is proposed that may maximise the number of patients classifiable as “Luminal-A like” and decrease the number for whom cytotoxic therapy is generally recommended.
Five serum proteins can distinguish between serum from women with breast cancer and healthy control subjects with high sensitivity and specificity and can significantly predict recurrence-free survival in women with estrogen receptor negative tumors.
A novel database of 1,172 mouse mammary tumor samples from 26 different major oncogenic mouse mammary tumor models reveals molecular features of mouse models and their relationships to human breast cancer.
rs10235235, which maps to the CYP3A locus, is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche, likely mediated via an effect on circulating hormone levels.
Reis-Filho and colleagues review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding, assessment and management of breast cancer.
From the blog
Aims & scope
Breast Cancer Research is an international, peer-reviewed online journal, publishing original research, reviews, editorials and reports. Open access research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal publishes preclinical, translational and clinical studies with a biological basis, including Phase I and Phase II trials.
All reviews, commentaries and reports published in Breast Cancer Research become free to access 6 months after publication. See below for the latest free review.
Kara N Maxwell, Katherine L NathansonBreast Cancer Research 2013, 15:212
(20 December 2013)
- 28 July 2014
- New insight into alternative treatment options for postmenopausal breast cancer patients using hormone therapy