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1:
Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB.
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The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells.
Breast Cancer Res. 2005;7(6):R1036-50. Epub 2005 Nov 2.
PMID: 16457685 [PubMed - indexed for MEDLINE]
2:
Bentel JM, Birrell SN, Pickering MA, Holds DJ, Horsfall DJ, Tilley WD.
Abstract
Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells.
Mol Cell Endocrinol. 1999 Aug 20;154(1-2):11-20.
PMID: 10509795 [PubMed - indexed for MEDLINE]
3:
Buchanan G, Birrell SN, Peters AA, Bianco-Miotto T, Ramsay K, Cops EJ, Yang M, Harris JM, Simila HA, Moore NL, Bentel JM, Ricciardelli C, Horsfall DJ, Butler LM, Tilley WD.
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Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.
Cancer Res. 2005 Sep 15;65(18):8487-96.
PMID: 16166329 [PubMed - indexed for MEDLINE]
4:
Palmieri D, Halverson DO, Ouatas T, Horak CE, Salerno M, Johnson J, Figg WD, Hollingshead M, Hursting S, Berrigan D, Steinberg SM, Merino MJ, Steeg PS.
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Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.
J Natl Cancer Inst. 2005 May 4;97(9):632-42.
PMID: 15870434 [PubMed - indexed for MEDLINE]
5:
Cops EJ, Bianco-Miotto T, Moore NL, Clarke CL, Birrell SN, Butler LM, Tilley WD.
Abstract
Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors.
J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):236-43. Epub 2008 Apr 20.
PMID: 18515094 [PubMed - indexed for MEDLINE]
6:
Hackenberg R, Schulz KD.
Abstract
Androgen receptor mediated growth control of breast cancer and endometrial cancer modulated by antiandrogen- and androgen-like steroids.
J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):113-7. Review.
PMID: 8603031 [PubMed - indexed for MEDLINE]
7:
Murphy LC, Dotzlaw H, Wong MS, Miller T, Murphy LJ.
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Mechanisms involved in the evolution of progestin resistance in human breast cancer cells.
Cancer Res. 1991 Apr 15;51(8):2051-7.
PMID: 1849041 [PubMed - indexed for MEDLINE]
8:
Hackenberg R, Hawighorst T, Filmer A, Nia AH, Schulz KD.
Abstract
Medroxyprogesterone acetate inhibits the proliferation of estrogen- and progesterone-receptor negative MFM-223 human mammary cancer cells via the androgen receptor.
Breast Cancer Res Treat. 1993;25(3):217-24.
PMID: 8369523 [PubMed - indexed for MEDLINE]
9:
Purmonen S, Manninen T, Pennanen P, Ylikomi T.
Abstract
Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells.
Oncol Rep. 2008 Jun;19(6):1627-34.
PMID: 18497975 [PubMed - indexed for MEDLINE]
10:
Zhang Z, Lundeen SG, Zhu Y, Carver JM, Winneker RC.
Abstract
In vitro characterization of trimegestone: a new potent and selective progestin.
Steroids. 2000 Oct-Nov;65(10-11):637-43.
PMID: 11108870 [PubMed - indexed for MEDLINE]
11:
Sugimoto T, Shiba E, Watanabe T, Takai S.
Abstract
Suppression of parathyroid hormone-related protein messenger RNA expression by medroxyprogesterone acetate in breast cancer tissues.
Breast Cancer Res Treat. 1999 Jul;56(1):11-23.
PMID: 10517339 [PubMed - indexed for MEDLINE]
12:
Sarvilinna N, Eronen H, Miettinen S, Vienonen A, Ylikomi T.
Abstract
Steroid hormone receptors and coregulators in endocrine-resistant and estrogen-independent breast cancer cells.
Int J Cancer. 2006 Feb 15;118(4):832-40.
PMID: 16152593 [PubMed - indexed for MEDLINE]
13:
Menendez JA, Oza BP, Colomer R, Lupu R.
Abstract
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
Int J Oncol. 2005 Jun;26(6):1507-15.
PMID: 15870863 [PubMed - indexed for MEDLINE]
14:
Wu J, Brandt S, Hyder SM.
Free Full Text
Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells.
Mol Endocrinol. 2005 Feb;19(2):312-26. Epub 2004 Nov 4.
PMID: 15528272 [PubMed - indexed for MEDLINE]
15:
Poulin R, Baker D, Poirier D, Labrie F.
Abstract
Multiple actions of synthetic 'progestins' on the growth of ZR-75-1 human breast cancer cells: an in vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids.
Breast Cancer Res Treat. 1991 Jan-Feb;17(3):197-210.
PMID: 1645605 [PubMed - indexed for MEDLINE]
16:
Salatino M, Beguelin W, Peters MG, Carnevale R, Proietti CJ, Galigniana MD, Vedoy CG, Schillaci R, Charreau EH, Sogayar MC, Elizalde PV.
Abstract
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Oncogene. 2006 Dec 14;25(59):7723-39. Epub 2006 Jun 26.
PMID: 16799639 [PubMed - indexed for MEDLINE]
17:
Poulin R, Baker D, Poirier D, Labrie F.
Abstract
Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.
Breast Cancer Res Treat. 1989 Mar;13(2):161-72.
PMID: 2525057 [PubMed - indexed for MEDLINE]
18:
Birrell SN, Hall RE, Tilley WD.
Abstract
Role of the androgen receptor in human breast cancer.
J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):95-103. Review.
PMID: 10819508 [PubMed - indexed for MEDLINE]
19:
Thuneke I, Schulte HM, Bamberger AM.
Abstract
Biphasic effect of medroxyprogesterone-acetate (MPA) treatment on proliferation and cyclin D1 gene transcription in T47D breast cancer cells.
Breast Cancer Res Treat. 2000 Oct;63(3):243-8.
PMID: 11110058 [PubMed - indexed for MEDLINE]
20:
Hanifi-Moghaddam P, Sijmons B, Ott MC, van Ijcken WF, Nowzari D, Kuhne EC, van der Spek P, Kloosterboer HJ, Burger CW, Blok LJ.
Free Full Text
The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line.
J Mol Endocrinol. 2006 Dec;37(3):405-13.
PMID: 17170081 [PubMed - indexed for MEDLINE]
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