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1:

Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status.

Fehm T, Becker S, Duerr-Stoerzer S, Sotlar K, Mueller V, Wallwiener D, Lane N, Solomayer E, Uhr J.

Breast Cancer Res. 2007;9(5):R74.

PMID: 17963511 [PubMed - indexed for MEDLINE]

2:

HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients.

Wülfing P, Borchard J, Buerger H, Heidl S, Zänker KS, Kiesel L, Brandt B.

Clin Cancer Res. 2006 Mar 15;12(6):1715-20.

PMID: 16551854 [PubMed - indexed for MEDLINE]

3:

Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer.

Ignatiadis M, Xenidis N, Perraki M, Apostolaki S, Politaki E, Kafousi M, Stathopoulos EN, Stathopoulou A, Lianidou E, Chlouverakis G, Sotiriou C, Georgoulias V, Mavroudis D.

J Clin Oncol. 2007 Nov 20;25(33):5194-202. Epub 2007 Oct 22.

PMID: 17954712 [PubMed - indexed for MEDLINE]

4:

Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer.

Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP.

Clin Breast Cancer. 2004 Jun;5(2):105-16. Review.

PMID: 15245613 [PubMed - indexed for MEDLINE]

5:

Serum epidermal growth factor receptor and HER2 expression in primary and metastatic breast cancer patients.

Asgeirsson KS, Agrawal A, Allen C, Hitch A, Ellis IO, Chapman C, Cheung KL, Robertson JF.

Breast Cancer Res. 2007;9(6):R75.

PMID: 17976236 [PubMed - indexed for MEDLINE]

6:

Circulating HER2 mRNA-positive cells in the peripheral blood of patients with stage I and II breast cancer after the administration of adjuvant chemotherapy: evaluation of their clinical relevance.

Apostolaki S, Perraki M, Pallis A, Bozionelou V, Agelaki S, Kanellou P, Kotsakis A, Politaki E, Kalbakis K, Kalykaki A, Vamvakas L, Georgoulias V, Mavroudis D.

Ann Oncol. 2007 May;18(5):851-8. Epub 2007 Feb 14. Erratum in: Ann Oncol. 2007 Nov;18(11):1916.

PMID: 17301075 [PubMed - indexed for MEDLINE]

7:

Central nervous system relapse in patients with breast cancer is associated with advanced stages, with the presence of circulating occult tumor cells and with the HER2/neu status.

Souglakos J, Vamvakas L, Apostolaki S, Perraki M, Saridaki Z, Kazakou I, Pallis A, Kouroussis C, Androulakis N, Kalbakis K, Millaki G, Mavroudis D, Georgoulias V.

Breast Cancer Res. 2006;8(4):R36.

PMID: 16846533 [PubMed - indexed for MEDLINE]

8:

High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer.

Jensen BV, Johansen JS, Price PA.

Clin Cancer Res. 2003 Oct 1;9(12):4423-34.

PMID: 14555515 [PubMed - indexed for MEDLINE]

9:

Changes of serum HER2 status during clinical course of metastatic breast cancer patients.

Fehm T, Jäger W, Kraemer S, Sohn C, Solomayer-Meyberg G, Solomayer EF, Kurek R, Wallwiener D, Gebauer G.

Anticancer Res. 2004 Nov-Dec;24(6):4205-10.

PMID: 15739264 [PubMed - indexed for MEDLINE]

10:

High circulating HER2 extracellular domain levels correlate with reduced efficacy of an aromatase inhibitor in hormone receptor-positive metastatic breast cancer: a confirmatory prospective study.

Colomer R, Llombart-Cussac A, Lloveras B, Ramos M, Mayordomo JI, Fernández R, Tusquets I, Gil M, Barnadas A, Constenla M, Gilabert M, Alba E.

Cancer. 2007 Nov 15;110(10):2178-85.

PMID: 17926331 [PubMed - indexed for MEDLINE]

11:

Quantification and phenotypic characterization of circulating tumor cells for monitoring response to a preventive HER2/neu vaccine-based immunotherapy for breast cancer: a pilot study.

Stojadinovic A, Mittendorf EA, Holmes JP, Amin A, Hueman MT, Ponniah S, Peoples GE.

Ann Surg Oncol. 2007 Dec;14(12):3359-68. Epub 2007 Sep 29.

PMID: 17906897 [PubMed - indexed for MEDLINE]

12:

Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden.

Cristofanilli M, Broglio KR, Guarneri V, Jackson S, Fritsche HA, Islam R, Dawood S, Reuben JM, Kau SW, Lara JM, Krishnamurthy S, Ueno NT, Hortobagyi GN, Valero V.

Clin Breast Cancer. 2007 Feb;7(6):471-9.

PMID: 17386124 [PubMed - indexed for MEDLINE]

13:

Molecular detection and prognostic value of circulating cytokeratin-19 messenger RNA-positive and HER2 messenger RNA-positive cells in the peripheral blood of women with early-stage breast cancer.

Ignatiadis M, Perraki M, Apostolaki S, Politaki E, Xenidis N, Kafousi M, Stathopoulos E, Lianidou E, Sotiriou C, Georgoulias V, Mavroudis D.

Clin Breast Cancer. 2007 Dec;7(11):883-9.

PMID: 18269779 [PubMed - indexed for MEDLINE]

14:

Metastatic breast cancer with HER2/neu-positive cells tends to have a morbid prognosis.

Emi Y, Kitamura K, Shikada Y, Kakeji Y, Takahashi I, Tsutsui S.

Surgery. 2002 Jan;131(1 Suppl):S217-21.

PMID: 11821814 [PubMed - indexed for MEDLINE]

15:

Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies.

Esteva FJ, Cheli CD, Fritsche H, Fornier M, Slamon D, Thiel RP, Luftner D, Ghani F.

Breast Cancer Res. 2005;7(4):R436-43. Epub 2005 Apr 8.

PMID: 15987448 [PubMed - indexed for MEDLINE]

16:

Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors.

Sunami E, Shinozaki M, Sim MS, Nguyen SL, Vu AT, Giuliano AE, Hoon DS.

Breast Cancer Res. 2008;10(3):R46. Epub 2008 May 16.

PMID: 18485221 [PubMed - indexed for MEDLINE]

17:

Evaluation of serum HER2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival.

Ludovini V, Gori S, Colozza M, Pistola L, Rulli E, Floriani I, Pacifico E, Tofanetti FR, Sidoni A, Basurto C, Rulli A, Crinò L.

Ann Oncol. 2008 May;19(5):883-90. Epub 2008 Jan 10.

PMID: 18187484 [PubMed - indexed for MEDLINE]

18:

Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer.

Ignatiadis M, Kallergi G, Ntoulia M, Perraki M, Apostolaki S, Kafousi M, Chlouverakis G, Stathopoulos E, Lianidou E, Georgoulias V, Mavroudis D.

Clin Cancer Res. 2008 May 1;14(9):2593-600.

PMID: 18451221 [PubMed - indexed for MEDLINE]

19:

Tumor histology and stage but not p53, Her2-neu or cathepsin-D expression are independent prognostic factors in breast cancer patients.

Korkolis DP, Tsoli E, Fouskakis D, Yiotis J, Koullias GJ, Giannopoulos D, Papalambros E, Nikiteas NI, Spiliopoulou CA, Patsouris E, Asimacopoulos P, Gorgoulis VG.

Anticancer Res. 2004 May-Jun;24(3b):2061-8.

PMID: 15274401 [PubMed - indexed for MEDLINE]

20:

Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancer.

Fehm T, Jäger W, Krämer S, Sohn C, Solomayer E, Wallwiener D, Gebauer G.

Anticancer Res. 2004 May-Jun;24(3b):1987-92.

PMID: 15274389 [PubMed - indexed for MEDLINE]

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