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McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID: 16854453 [PubMed - indexed for MEDLINE]

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway.

DeGraffenried LA, Fulcher L, Friedrichs WE, Grünwald V, Ray RB, Hidalgo M.

Ann Oncol. 2004 Oct;15(10):1510-6.

PMID: 15367412 [PubMed - indexed for MEDLINE]

Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ, Sonenshein GE.

Oncogene. 2001 Mar 15;20(11):1287-99.

PMID: 11313873 [PubMed - indexed for MEDLINE]

Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma.

Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y.

Breast Cancer Res Treat. 2007 Mar;101(3):249-57. Epub 2006 Sep 28.

PMID: 17006756 [PubMed - indexed for MEDLINE]

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase.

Mahimainathan L, Choudhury GG.

J Biol Chem. 2004 Apr 9;279(15):15258-68. Epub 2004 Jan 12.

PMID: 14718524 [PubMed - indexed for MEDLINE]

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PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.

Oncogene. 2002 Aug 8;21(34):5289-300.

PMID: 12149650 [PubMed - indexed for MEDLINE]

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Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.

Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA.

Cancer Res. 2002 Jul 1;62(13):3729-35.

PMID: 12097282 [PubMed - indexed for MEDLINE]

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PTEN, more than the AKT pathway.

Blanco-Aparicio C, Renner O, Leal JF, Carnero A.

Carcinogenesis. 2007 Jul;28(7):1379-86. Epub 2007 Mar 6. Review.

PMID: 17341655 [PubMed - indexed for MEDLINE]

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Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.

Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N.

J Immunol. 2008 Mar 15;180(6):4218-26.

PMID: 18322234 [PubMed - indexed for MEDLINE]

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PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.

Fang J, Ding M, Yang L, Liu LZ, Jiang BH.

Cell Signal. 2007 Dec;19(12):2487-97. Epub 2007 Aug 15.

PMID: 17826033 [PubMed - indexed for MEDLINE]

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Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation.

Servidei T, Riccardi A, Sanguinetti M, Dominici C, Riccardi R.

J Cell Physiol. 2006 Jul;208(1):220-8.

PMID: 16575905 [PubMed - indexed for MEDLINE]

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Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines.

Festuccia C, Muzi P, Millimaggi D, Biordi L, Gravina GL, Speca S, Angelucci A, Dolo V, Vicentini C, Bologna M.

Endocr Relat Cancer. 2005 Dec;12(4):983-98.

PMID: 16322337 [PubMed - indexed for MEDLINE]

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PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.

Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM.

Gastroenterology. 2002 Oct;123(4):1163-78.

PMID: 12360479 [PubMed - indexed for MEDLINE]

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Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.

Kandasamy K, Srivastava RK.

Cancer Res. 2002 Sep 1;62(17):4929-37.

PMID: 12208743 [PubMed - indexed for MEDLINE]

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The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.

Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ.

Mol Biol Cell. 2007 May;18(5):1768-80. Epub 2007 Mar 1.

PMID: 17332506 [PubMed - indexed for MEDLINE]

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PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

Weng LP, Smith WM, Dahia PL, Ziebold U, Gil E, Lees JA, Eng C.

Cancer Res. 1999 Nov 15;59(22):5808-14.

PMID: 10582703 [PubMed - indexed for MEDLINE]

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