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1:

TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells.

Simeone AM, McMurtry V, Nieves-Alicea R, Saavedra JE, Keefer LK, Johnson MM, Tari AM.

Breast Cancer Res. 2008;10(3):R44. Epub 2008 May 12.

PMID: 18474097 [PubMed - indexed for MEDLINE]

2:

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

Shami PJ, Saavedra JE, Wang LY, Bonifant CL, Diwan BA, Singh SV, Gu Y, Fox SD, Buzard GS, Citro ML, Waterhouse DJ, Davies KM, Ji X, Keefer LK.

Mol Cancer Ther. 2003 Apr;2(4):409-17.

PMID: 12700285 [PubMed - indexed for MEDLINE]

3:

Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase.

Park MJ, Park IC, Hur JH, Kim MS, Lee HC, Woo SH, Lee KH, Rhee CH, Hong SI, Lee SH.

J Neurosurg. 2002 Jul;97(1):112-8.

PMID: 12134900 [PubMed - indexed for MEDLINE]

4:

Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation.

Liu J, Li C, Qu W, Leslie E, Bonifant CL, Buzard GS, Saavedra JE, Keefer LK, Waalkes MP.

Mol Cancer Ther. 2004 Jun;3(6):709-14.

PMID: 15210857 [PubMed - indexed for MEDLINE]

5:

Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.

Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ, Shao ZM.

Breast Cancer Res. 2007;9(6):R76.

PMID: 17980029 [PubMed - indexed for MEDLINE]

6:

Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro.

Balduyck M, Zerimech F, Gouyer V, Lemaire R, Hemon B, Grard G, Thiebaut C, Lemaire V, Dacquembronne E, Duhem T, Lebrun A, Dejonghe MJ, Huet G.

Clin Exp Metastasis. 2000;18(2):171-8.

PMID: 11235993 [PubMed - indexed for MEDLINE]

7:

3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases.

Xie Z, Yuan H, Yin Y, Zeng X, Bai R, Glazer RI.

BMC Cancer. 2006 Mar 21;6:77.

PMID: 16551362 [PubMed - indexed for MEDLINE]

8:

Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.

Ramer R, Hinz B.

J Natl Cancer Inst. 2008 Jan 2;100(1):59-69. Epub 2007 Dec 25.

PMID: 18159069 [PubMed - indexed for MEDLINE]

9:

Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells.

Ramer R, Eichele K, Hinz B.

Oncogene. 2007 Aug 23;26(39):5822-7. Epub 2007 Mar 19.

PMID: 17369856 [PubMed - indexed for MEDLINE]

10:

In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells.

Paquette B, Baptiste C, Therriault H, Arguin G, Plouffe B, Lemay R.

Br J Cancer. 2007 Dec 3;97(11):1505-12. Epub 2007 Nov 6.

PMID: 17987037 [PubMed - indexed for MEDLINE]

11:

Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

Shami PJ, Saavedra JE, Bonifant CL, Chu J, Udupi V, Malaviya S, Carr BI, Kar S, Wang M, Jia L, Ji X, Keefer LK.

J Med Chem. 2006 Jul 13;49(14):4356-66.

PMID: 16821795 [PubMed - indexed for MEDLINE]

12:

Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors.

Kousidou OC, Mitropoulou TN, Roussidis AE, Kletsas D, Theocharis AD, Karamanos NK.

Int J Oncol. 2005 Apr;26(4):1101-9.

PMID: 15754008 [PubMed - indexed for MEDLINE]

13:

Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer.

Lee YK, So IS, Lee SC, Lee JH, Lee CW, Kim WM, Park MK, Lee ST, Park DY, Shin DY, Park CU, Kim YS.

J Gene Med. 2005 Feb;7(2):145-57.

PMID: 15546163 [PubMed - indexed for MEDLINE]

15:

Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.

Kwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI.

Mol Cancer Res. 2006 Mar;4(3):209-20.

PMID: 16547158 [PubMed - indexed for MEDLINE]

16:

JS-K, a novel non-ionic diazeniumdiolate derivative, inhibits Hep 3B hepatoma cell growth and induces c-Jun phosphorylation via multiple MAP kinase pathways.

Ren Z, Kar S, Wang Z, Wang M, Saavedra JE, Carr BI.

J Cell Physiol. 2003 Dec;197(3):426-34.

PMID: 14566972 [PubMed - indexed for MEDLINE]

17:

JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells.

Udupi V, Yu M, Malaviya S, Saavedra JE, Shami PJ.

Leuk Res. 2006 Oct;30(10):1279-83. Epub 2006 Jan 24.

PMID: 16439016 [PubMed - indexed for MEDLINE]

18:

Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells.

Tantivejkul K, Vucenik I, Shamsuddin AM.

Anticancer Res. 2003 Sep-Oct;23(5A):3671-9.

PMID: 14666663 [PubMed - indexed for MEDLINE]

20:

[Regulation of matrix-degrading enzymes in gynecologic cancer tissues and cells]

Kikkawa F.

Nippon Sanka Fujinka Gakkai Zasshi. 1996 Aug;48(8):618-22. Japanese.

PMID: 8808829 [PubMed - indexed for MEDLINE]

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