http://breast-cancer-research.com/content/11/1/R3/comments The latest comments on the article 'Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression' 2009-02-19T11:03:44Z http://breast-cancer-research.com/content/11/1/R3/comments#331645 <p>I read the article, "Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression" by Holliday et al with great interest. However, I was disappointed to note that while the authors included references for homotypic <br/>three-dimensional cultures, citations pertinent to their paper were omitted. Specifically, original articles describing heterotypic interactions between breast cancer cells and stromal cells (the microenvironment), and the dominant role the microenvironment plays in breast tumorigenesis were omitted. Although citing these papers would indicate that the authors of this paper are not the first to report on multicellular interactions in three-dimensional tricultures, inclusion of these papers in their article would provide a better discussion of their findings. <br/> <br/>I have included the references to these papers. <br/> <br/>Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and <br/>progression. Shekhar MP, Werdell J, Santner SJ, Pauley RJ, Tait L.; Cancer Res. 2001, Feb 15;61(4):1320-6. <br/> <br/>Interaction with endothelial cells is a prerequisite for branching ductal-alveolar morphogenesis and hyperplasia of preneoplastic human breast epithelial cells: regulation by estrogen. Shekhar MP, Werdell J, Tait L. Cancer Res. 2000 Jan 15;60(2):439-49. <br/> <br/></p> Malathy Shekhar 2009-02-19T11:03:44Z http://breast-cancer-research.com/content/11/1/R3 Holliday et al. Breast Cancer Research 11 R3 Mon Jan 19 00:00:00 GMT 2009